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https://hdl.handle.net/1959.11/7994
Title: | Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems | Contributor(s): | Daines, Alison M (author); Greatrex, Ben (author) ; Hayman, Colin M (author); Hook, Sarah M (author); McBurney, Warren T (author); Rades, Thomas (author); Rendle, Phillip M (author); Sims, Ian M (author) | Publication Date: | 2009 | DOI: | 10.1016/j.bmc.2009.05.043 | Handle Link: | https://hdl.handle.net/1959.11/7994 | Abstract: | Immunostimulatory saponin based colloidal antigen delivery systems show promise as adjuvants for subunit vaccines. For this reason, allyl oleanolate was glycosylated at the 3-position using trichloroacetimidate donors to give monodesmodic saponins following deprotection. Bisdesmodic saponins were synthesized by double glycosylation at the 3- and 28-positions of oleanolic acid. When formulated together with cholesterol and phospholipids, ring-like, helical and rod-like nanostructures were formed depending on the saponin concentrations used. As an indication of adjuvant activity, the ability of these formulations, and the saponins by themselves, to induce dendritic cell maturation was measured, but no significant activity was observed. | Publication Type: | Journal Article | Source of Publication: | Bioorganic & Medicinal Chemistry, 17(14), p. 5207-5218 | Publisher: | Pergamon Press | Place of Publication: | United Kingdom | ISSN: | 1464-3391 0968-0896 |
Fields of Research (FoR) 2008: | 030405 Molecular Medicine 030401 Biologically Active Molecules 030503 Organic Chemical Synthesis |
Socio-Economic Objective (SEO) 2008: | 970103 Expanding Knowledge in the Chemical Sciences 970106 Expanding Knowledge in the Biological Sciences 920108 Immune System and Allergy |
Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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