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Title: The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers
Contributor(s): Greatrex, Ben  (author)orcid ; Brodie, Samuel J (author); Furneaux, Richard H (author); Hook, Sarah M (author); McBurney, Warren T (author); Painter, Gavin F (author); Rades, Thomas (author); Rendle, Phillip M (author)
Publication Date: 2009
DOI: 10.1016/j.tet.2009.02.018
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Abstract: The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-α-d-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell maturation was measured, however, no significant trends were observed.
Publication Type: Journal Article
Source of Publication: Tetrahedron, 65(15), p. 2939-2950
Publisher: Pergamon
Place of Publication: United Kingdom
ISSN: 1464-5416
Field of Research (FoR) 2008: 110704 Cellular Immunology
030503 Organic Chemical Synthesis
Socio-Economic Objective (SEO) 2008: 970103 Expanding Knowledge in the Chemical Sciences
970106 Expanding Knowledge in the Biological Sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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