The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers

Title
The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers
Publication Date
2009
Author(s)
Greatrex, Ben
( author )
OrcID: https://orcid.org/0000-0002-0356-4966
Email: bgreatre@une.edu.au
UNE Id une-id:bgreatre
Brodie, Samuel J
Furneaux, Richard H
Hook, Sarah M
McBurney, Warren T
Painter, Gavin F
Rades, Thomas
Rendle, Phillip M
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Elsevier Ltd
Place of publication
United Kingdom
DOI
10.1016/j.tet.2009.02.018
UNE publication id
une:8166
Abstract
The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-α-d-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell maturation was measured, however, no significant trends were observed.
Link
Citation
Tetrahedron, 65(15), p. 2939-2950
ISSN
1464-5416
0040-4020
Start page
2939
End page
2950

Files:

NameSizeformatDescriptionLink