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Title: Comparison of alternatives to in-feed antimicrobials for the prevention of clinical necrotic enteritis
Contributor(s): Geier, M (author); Mikkelsen, Lene Lind  (author); Torok, VA (author); Allison, Glenys M (author); Olnood, CG (author); Boulianne, N (author); Hughes, RJ (author); Choct, Mingan  (author)orcid 
Publication Date: 2010
DOI: 10.1111/j.1365-2672.2010.04758.x
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Abstract: Aims:  The capacity for 'Lactobacillus johnsonii' and an organic acid (OA) blend to prevent 'Clostridium perfringens'-induced clinical necrotic enteritis (NE) in chickens was studied. Methods and Results:  Cobb 500 birds were allocated into six groups (n = 25 birds/pen, eight pens/treatment); Unchallenged, Challenged, Antimicrobial (zinc bacitracin (ZnB)/monensin), OA, probiotic 'Lact. johnsonii' and probiotic sham (Phosphate–buffered saline). All birds were challenged with 'Eimeria' spp. and 'Cl. perfringens' except for unchallenged controls. Birds fed antimicrobials were protected from NE development as indicated by maintenance of body weight, low mortality and clostridium levels, and decreased intestinal macroscopic lesion scores compared to challenged controls (P < 0·05). 'Lactobacillus johnsonii'-fed birds had reduced lesion scores, whilst OA-fed birds had decreased 'Cl. perfringens' levels. Both 'Lact. johnsonii' and OA-fed birds had improved feed efficiency between days 0 and 28 compared to challenged controls; however, mortality and body weights were not improved by either treatment. Microbial profiling indicated that the challenge procedure significantly altered the jejunal microbiota. The microbiota of antimicrobial-fed birds was significantly different from all other groups. Conclusions:  Whilst 'Lact. johnsonii' and OA altered specific intestinal parameters, significant protection against NE was not observed. Significance and Impact of the Study:  'Lactobacillus johnsonii' and OA did not prevent NE; however, some improvements were evident. Other related treatments, or combinations of these two treatments, may provide greater protection.
Publication Type: Journal Article
Source of Publication: Journal of Applied Microbiology, 109(4), p. 1329-1338
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: United Kingdom
ISSN: 1364-5072
Field of Research (FOR): 070204 Animal Nutrition
Socio-Economic Objective (SEO): 830309 Poultry
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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