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https://hdl.handle.net/1959.11/752
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DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Hong | en |
dc.contributor.author | Van Der Werf, JH | en |
dc.date.accessioned | 2008-07-31T14:40:00Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Genetics Selection Evolution, 36(2), p. 145-161 | en |
dc.identifier.issn | 1297-9686 | en |
dc.identifier.issn | 0999-193X | en |
dc.identifier.uri | https://hdl.handle.net/1959.11/752 | - |
dc.description.abstract | In a simulation study, different designs were compared for efficiency of fine-mapping of QTL. The variance component method for fine-mapping of QTL was used to estimate QTL position and variance components. The design of many families with small size gave a higher mapping resolution than a design with few families of large size. However, the difference is small in half sib designs. The proportion of replicates with the QTL positioned within 3 cM of the true position is 0.71 in the best design, and 0.68 in the worst design applied to 128 animals with a phenotypic record and a QTL explaining 25% of the phenotypic variance. The design of two half sib families each of size 64 was further investigated for a hypothetical population with effective size of 1000 simulated for 6000 generations with a marker density of 0.25 cM and with marker mutation rate 4 x 10<sup>-4</sup> per generation.In mapping using bi-allelic markers, 42~55% of replicated simulations could position QTL within 0.75 cM of the true position whereas this was higher for multi allelic markers (48~76%). The accuracy was lowest (48%) when mutation age was 100 generations and increased to 68% and 76% for mutation ages of 200 and 500 generations, respectively, after which it was about 70% for mutation ages of 1000 generations and older. When effective size was linearly decreasing in the last 50 generations, the accuracy was decreased (56 to 70%). We show that half sib designs that have often been used for linkage mapping can have sufficient information for fine-mapping of QTL. It is suggested that the same design with the same animals for linkage mapping should be used for fine-mapping so gene mapping can be cost effective in livestock populations. | en |
dc.language | en | en |
dc.publisher | BioMed Central Ltd | en |
dc.relation.ispartof | Genetics Selection Evolution | en |
dc.title | Efficient designs for fine-mapping of quantitative trait loci using combined linkage disequilibrium and linkage | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1051/gse:2003056 | en |
dcterms.accessRights | UNE Green | en |
dc.subject.keywords | Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.contributor.firstname | Sang Hong | en |
local.contributor.firstname | JH | en |
local.subject.for2008 | 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics) | en |
local.subject.seo | 630199 Livestock not elsewhere classified | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.school | School of Environmental and Rural Science | en |
local.profile.email | slee38@une.edu.au | en |
local.profile.email | jvanderw@une.edu.au | en |
local.output.category | C1 | en |
local.record.place | au | en |
local.record.institution | University of New England | en |
local.identifier.epublicationsrecord | pes:1727 | en |
local.publisher.place | United Kingdom | en |
local.format.startpage | 145 | en |
local.format.endpage | 161 | en |
local.identifier.scopusid | 1442338504 | en |
local.peerreviewed | Yes | en |
local.identifier.volume | 36 | en |
local.identifier.issue | 2 | en |
local.access.fulltext | Yes | en |
local.contributor.lastname | Lee | en |
local.contributor.lastname | Van Der Werf | en |
dc.identifier.staff | une-id:slee38 | en |
dc.identifier.staff | une-id:jvanderw | en |
local.profile.orcid | 0000-0003-2512-1696 | en |
local.profile.role | author | en |
local.profile.role | author | en |
local.identifier.unepublicationid | une:765 | en |
dc.identifier.academiclevel | Academic | en |
dc.identifier.academiclevel | Academic | en |
local.title.maintitle | Efficient designs for fine-mapping of quantitative trait loci using combined linkage disequilibrium and linkage | en |
local.output.categorydescription | C1 Refereed Article in a Scholarly Journal | en |
local.search.author | Lee, Sang Hong | en |
local.search.author | Van Der Werf, JH | en |
local.open.fileurl | https://rune.une.edu.au/web/retrieve/669c248c-81b7-4112-8d5b-4a082c0a7885 | en |
local.uneassociation | Unknown | en |
local.identifier.wosid | 000188936300001 | en |
local.year.published | 2004 | en |
local.fileurl.open | https://rune.une.edu.au/web/retrieve/669c248c-81b7-4112-8d5b-4a082c0a7885 | en |
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format | |
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open/SOURCE02.pdf | Publisher version (open access) | 216.08 kB | Adobe PDF Download Adobe | View/Open |
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