Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/7497
Title: The medial prefrontal cortex and memory of cue location in the rat
Contributor(s): Rawson, Timothy (author); O'Kane, Michael (author); Talk, Andrew  (author)orcid 
Publication Date: 2010
DOI: 10.1016/j.nlm.2009.09.003
Handle Link: https://hdl.handle.net/1959.11/7497
Abstract: We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoidance response, but both lesioned and control subjects avoided the cue itself when presented at test. A follow up assessment revealed no spatial learning impairment in either group. These findings suggest that the rodent mPFC is required for incidental learning or recollection of the location at which a discrete cue occurred, but is not required for cue recognition or for allocentric spatial memory.
Publication Type: Journal Article
Source of Publication: Neurobiology of Learning and Memory, 93(1), p. 132-136
Publisher: Academic Press
Place of Publication: United States of America
ISSN: 1074-7427
1095-9564
Field of Research (FOR): 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio-Economic Objective (SEO): 920410 Mental Health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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