Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/7473
Title: | Increased plasma ᴅ-lactic acid associated with impaired memory in rats | Contributor(s): | Hanstock, Tanya (author); Mallet, Paul E (author); Clayton, EH (author) | Publication Date: | 2010 | DOI: | 10.1016/j.physbeh.2010.09.018 | Handle Link: | https://hdl.handle.net/1959.11/7473 | Abstract: | Aim: ᴅ-Lactic acidosis is associated with memory impairment in humans. Recent research indicates that ᴅ-lactic acid may inhibit the supply of energy from astrocytes to neurons involved with memory formation. However, little is known about the effects of increased hind-gut fermentation due to changes in diet on circulating lactic acid concentrations and memory. Method: Thirty-six male Wistar rats were fed three dietary treatments: a commercial rat and mouse chow, a soluble carbohydrate based diet or a fermentable carbohydrate based diet. The parameters estimating memory were examined by employing the object recognition test. Physical parameters of fermentation including hind-gut and plasma lactic acid concentrations were examined after sacrifice, either 3 or 21 h after feeding. Results: Increased fermentation in the hind-gut of rats, indicated by lower caecum pH, was associated with increased plasma L-lactic acid (r=-0.41, p=0.020) and ᴅ-lactic acid (r=-0.33, p=0.087). Memory, being able to discriminate between a familiar and a novel object during the object recognition test, was reduced with increasing plasma ᴅ-lactic acid (r=−0.51, p=0.021). Conclusions: Memory impairment was associated with alterations in plasma ᴅ-lactic acid following the fermentation of carbohydrate in the hind-gut. Further work is still required to determine whether these effects are mediated centrally or via direct connections through the enteric nervous system. | Publication Type: | Journal Article | Source of Publication: | Physiology & Behavior, 101(5), p. 653-659 | Publisher: | Elsevier Inc | Place of Publication: | United States of America | ISSN: | 1873-507X 0031-9384 |
Fields of Research (FoR) 2008: | 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | Socio-Economic Objective (SEO) 2008: | 920401 Behaviour and Health | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
---|---|
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.