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https://hdl.handle.net/1959.11/7421
Title: | A review of the neurobiological effects of psychotherapy for depression | Contributor(s): | Sharpley, Chris (author) | Publication Date: | 2010 | DOI: | 10.1037/a0021177 | Handle Link: | https://hdl.handle.net/1959.11/7421 | Abstract: | Although randomized, controlled clinical trials have shown that different forms of psychotherapy may be efficacious for depression, psychotherapy has not been widely reported to have effects upon the neurobiological concomitants of depression in similar ways as medication. Neuroendocrinal changes that occur during depression (principally hypercortisolaemia) produce structural and functional alterations to the prefrontal cortex, hippocampus, and amygdala, plus the connectivity between these regions of the brain. This article reviews the evidence to date regarding the neurobiological effects of psychotherapy for depression and suggests a hypothetical pathway linking the nurturing effects of the therapist–patient "bond" and restoration of neuroendocrinal "balance." This pathway may provide a neurobiological causal link between psychotherapy and alleviation of depression in the same way as that which exists for pharmacological treatments, and argues for a model of depression that includes both biological and psychological effects of psychotherapy when considering treatment choice and application. | Publication Type: | Journal Article | Source of Publication: | Psychotherapy, 47(4), p. 603-615 | Publisher: | American Psychological Association | Place of Publication: | United States of America | ISSN: | 1939-1536 0033-3204 |
Fields of Research (FoR) 2008: | 110319 Psychiatry (incl Psychotherapy) | Fields of Research (FoR) 2020: | 320903 Central nervous system | Socio-Economic Objective (SEO) 2008: | 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | Socio-Economic Objective (SEO) 2020: | 200409 Mental health | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article School of Science and Technology |
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