Lee, Seung Hwan; Van Der Werf, Julius H; Lee, S H; Park, E W; Oh, S J; Gibson, John; Thompson, John M

Author(s)

Lee, Seung Hwan

Van Der Werf, Julius H

Lee, S H

Park, E W

Oh, S J

Gibson, John

Thompson, John M

Publication Date

2010

Abstract

The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).

Citation

Animal Genetics, 41(4), p. 442-444

ISSN

1365-2052

0268-9146

0268-9154

Link

https://hdl.handle.net/1959.11/7221

Publisher

Wiley-Blackwell Publishing Ltd

Title

Genetic polymorphisms of the bovine 'Fatty acid binding protein 4' gene are significantly associated with marbling and carcass weight in Hanwoo ('Korean Cattle')

Type of document

Journal Article

Entity Type

Publication

Author(s)	Lee, Seung Hwan Van Der Werf, Julius H Lee, S H Park, E W Oh, S J Gibson, John Thompson, John M
Publication Date	2010
Abstract	The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).
Citation	Animal Genetics, 41(4), p. 442-444
ISSN	1365-2052 0268-9146 0268-9154
Link	https://hdl.handle.net/1959.11/7221
Publisher	Wiley-Blackwell Publishing Ltd
Title	Genetic polymorphisms of the bovine 'Fatty acid binding protein 4' gene are significantly associated with marbling and carcass weight in Hanwoo ('Korean Cattle')
Type of document	Journal Article
Entity Type	Publication

Genetic polymorphisms of the bovine 'Fatty acid binding protein 4' gene are significantly associated with marbling and carcass weight in Hanwoo ('Korean Cattle')

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