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Title: Genetic polymorphisms of the bovine 'Fatty acid binding protein 4' gene are significantly associated with marbling and carcass weight in Hanwoo ('Korean Cattle')
Contributor(s): Lee, Seung Hwan (author); Van Der Werf, Julius H  (author)orcid ; Lee, S H (author); Park, E W (author); Oh, S J (author); Gibson, John  (author); Thompson, John M  (author)
Publication Date: 2010
DOI: 10.1111/j.1365-2052.2010.02024.x
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Abstract: The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).
Publication Type: Journal Article
Source of Publication: Animal Genetics, 41(4), p. 442-444
Publisher: Wiley-Blackwell Publishing Ltd
Place of Publication: Oxford, United Kingdom
ISSN: 0268-9146
Field of Research (FOR): 070201 Animal Breeding
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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