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|Title:||Genetic polymorphisms of the bovine 'Fatty acid binding protein 4' gene are significantly associated with marbling and carcass weight in Hanwoo ('Korean Cattle')||Contributor(s):||Lee, Seung Hwan (author); Van Der Werf, Julius H (author) ; Lee, S H (author); Park, E W (author); Oh, S J (author); Gibson, John (author); Thompson, John M (author)||Publication Date:||2010||DOI:||10.1111/j.1365-2052.2010.02024.x||Handle Link:||https://hdl.handle.net/1959.11/7221||Abstract:||The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT (P = 0.01) and the g.3631G allele was associated with higher marbling score (P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT (P = 0.02) and marbling score (P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).||Publication Type:||Journal Article||Source of Publication:||Animal Genetics, 41(4), p. 442-444||Publisher:||Wiley-Blackwell Publishing Ltd||Place of Publication:||Oxford, United Kingdom||ISSN:||0268-9146
|Field of Research (FOR):||070201 Animal Breeding||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 359
|Appears in Collections:||Journal Article|
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