Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/7193
Title: Evaluating haplotype diversity within and between Australian sheep breeds
Contributor(s): Goodswen, Stephen (author); Gondro, Cedric (author)orcid ; Kadarmideen, H N (author); Van Der Werf, Julius H (author)orcid 
Publication Date: 2010
Handle Link: https://hdl.handle.net/1959.11/7193
Abstract: Genomic data can be used to predict differences in phenotype or breeding values between individuals, using linkage disequilibrium (LD) between marker and putative quantitative trait loci (QTL). So far, most genome association studies are based on genotypes at individual loci, and although this has given reasonable accuracies of predicting breeding value (Roos et al. (2008)), there is limited evidence of underlying QTL effects being consistant at the basis of such predictions. One problem with single markers in dense genotypic data is that different loci can easily be in LD by random chance, and SNPs apparently linked to QTL effects may have limited predictive ability in data from individuals that are genetically less related. When using ordered genotypes and information on haplotype similarity, the power of predicting QTL effects can be increased. If two individuals share the same extended haplotype over the same genomic region, the chance that they carry the same marker-QTL allele relationship by descent is much higher. In this paper, we explore the extent by which various haplotype lengths are shared within and between 4 Australian sheep breeds. We count how many haplotypes are present in the breed for a given number of loci, and how many of these haplotypes are shared between breeds. Such statistics will become important when assessing identity by descent (IBD) probabilities and how well these can be separated from identity by state (IBS) probabilities.
Publication Type: Conference Publication
Conference Name: 9th World Congress on Genetics Applied to Livestock Production (WCGALP), Leipzig, Germany, 1-6 August, 2010
Conference Details: 9th World Congress on Genetics Applied to Livestock Production (WCGALP), Leipzig, Germany, 1-6 August, 2010
Source of Publication: Proceedings of the 9th World Congress on Genetics Applied to Livestock Production
Publisher: German Society for Animal Science
Place of Publication: Germany
Field of Research (FOR): 060411 Population, Ecological and Evolutionary Genetics
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://www.kongressband.de/wcgalp2010/assets/html/0947.htm
http://www.wcgalp2010.org/
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