Genetics of Global Gene Expression Patterns and Gene Networks Affecting Muscling in Sheep

Title
Genetics of Global Gene Expression Patterns and Gene Networks Affecting Muscling in Sheep
Publication Date
2010
Author(s)
Kadarmideen, H N
Watson-Haigh, N
Kijas, J W
Vuocolo, T
Byrne, K
Gondro, Cedric
( author )
OrcID: https://orcid.org/0000-0003-0666-656X
Email: cgondro2@une.edu.au
UNE Id une-id:cgondro2
Oddy, Hutton
( author )
OrcID: https://orcid.org/0000-0003-1783-1049
Email: hoddy2@une.edu.au
UNE Id une-id:hoddy2
Gardner, Graham E
Tellam, R L
Editor
Editor(s): Gesellschaft für Tierzuchtwissenschaften e. V.
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
German Society for Animal Science
Place of publication
Germany
UNE publication id
une:7358
Abstract
The Sheep Genomics research program in Australia has undertaken a range of investigations to identify genes and DNA markers contributing to increase in size and altered distribution of muscling in sheep breeds (Oddy et al. 2007). The main objectives of this study were: (i) to discover key genes and pathways underlying muscling traits by expression profiling of skeletal muscle from sheep born to industry sires with high and low genetic merit (Estimated Breeding Values or EBVs) for eye muscle depth (EMD), and analysing the resulting expression data by advanced bioinformatics / systems genetics approaches, and; (ii) to link high throughput genetic information on these animals (single nucleotide polymorphisms or SNPs) with gene expression profiles of highly differentially expressed genes and highly connected regulatory (hub) genes identified in the first objective. With these approaches, we can generate a comprehensive understanding of the molecular mechanisms underpinning muscle hypertrophy phenotypes in sheep and identify potential candidate genes that can be used in breeding programs to improve meat quantity.
Link
Citation
Proceedings of the 9th World Congress on Genetics Applied to Livestock Production
ISBN
9783000316081

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