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Title: Genetics of Global Gene Expression Patterns and Gene Networks Affecting Muscling in Sheep
Contributor(s): Kadarmideen, H N (author); Watson-Haigh, N (author); Kijas, J W (author); Vuocolo, T (author); Byrne, K (author); Gondro, Cedric  (author)orcid ; Oddy, Hutton  (author)orcid ; Gardner, Graham E (author); Tellam, R L (author)
Publication Date: 2010
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Abstract: The Sheep Genomics research program in Australia has undertaken a range of investigations to identify genes and DNA markers contributing to increase in size and altered distribution of muscling in sheep breeds (Oddy et al. 2007). The main objectives of this study were: (i) to discover key genes and pathways underlying muscling traits by expression profiling of skeletal muscle from sheep born to industry sires with high and low genetic merit (Estimated Breeding Values or EBVs) for eye muscle depth (EMD), and analysing the resulting expression data by advanced bioinformatics / systems genetics approaches, and; (ii) to link high throughput genetic information on these animals (single nucleotide polymorphisms or SNPs) with gene expression profiles of highly differentially expressed genes and highly connected regulatory (hub) genes identified in the first objective. With these approaches, we can generate a comprehensive understanding of the molecular mechanisms underpinning muscle hypertrophy phenotypes in sheep and identify potential candidate genes that can be used in breeding programs to improve meat quantity.
Publication Type: Conference Publication
Conference Details: WCGALP 2010: 9th World Congress on Genetics Applied to Livestock Production, Leipzig, Germany, 1-6 August, 2010
Source of Publication: Proceedings of the 9th World Congress on Genetics Applied to Livestock Production
Publisher: German Society for Animal Science
Place of Publication: Germany
Fields of Research (FoR) 2008: 070201 Animal Breeding
060405 Gene Expression (incl Microarray and other genome-wide approaches)
Socio-Economic Objective (SEO) 2008: 830310 Sheep - Meat
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
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