Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/6881
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dc.contributor.authorClayton, EHen
dc.contributor.authorHanstock, Tanyaen
dc.contributor.authorHirneth, SJen
dc.contributor.authorKable, CJen
dc.contributor.authorGarg, MLen
dc.contributor.authorHazell, PLen
dc.date.accessioned2010-11-19T09:48:00Z-
dc.date.issued2008-
dc.identifier.citationLipids, 43(11), p. 1031-1038en
dc.identifier.issn1558-9307en
dc.identifier.issn0024-4201en
dc.identifier.urihttps://hdl.handle.net/1959.11/6881-
dc.description.abstractReduced long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported in adult patients suffering from depression and bipolar disorder (BD). LCn-3PUFA status has not previously been examined in children and adolescents with BD compared with healthy controls. Fifteen children and adolescents (9–18 years, M ± SD = 14.4 ± 3.48) diagnosed with juvenile bipolar disorder (JBD) and fifteen healthy age and sex-matched controls were assessed for dietary intake and fasting red blood cell (RBC) membrane concentrations of LCn-3PUFA. Fatty acid concentrations were compared between participants diagnosed with JBD and controls after controlling for dietary intake. RBC membrane concentrations of EPA and DHA were not significantly lower in participants diagnosed with JBD compared with healthy controls (M ± sem EPA = 3.37 ± 0.26 vs. 3.69 ± 0.27 lg/mL, P = 0.458; M ± sem DHA = 22.08 ± 2.23 vs. 24.61 ± 2.38 lg/mL, P = 0.528) after controlling for intake. Red blood cell DHA was negatively (r = -0.55; P = 0.044) related to clinician ratings of depression. Although lower RBC concentrations of LCn-3PUFA were explained by lower intakes in the current study, previous evidence has linked reduced LCn-3PUFA to the aetiology of BD. As RBC DHA was also negatively related to symptoms of depression, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this patient population.en
dc.languageenen
dc.publisherSpringeren
dc.relation.ispartofLipidsen
dc.titleLong-Chain Omega-3 Polyunsaturated Fatty Acids in the Blood of Children and Adolescents with Juvenile Bipolar Disorderen
dc.typeJournal Articleen
dc.identifier.doi10.1007/s11745-008-3224-zen
dc.subject.keywordsHealth, Clinical and Counselling Psychologyen
local.contributor.firstnameEHen
local.contributor.firstnameTanyaen
local.contributor.firstnameSJen
local.contributor.firstnameCJen
local.contributor.firstnameMLen
local.contributor.firstnamePLen
local.subject.for2008170106 Health, Clinical and Counselling Psychologyen
local.subject.seo2008920410 Mental Healthen
local.profile.schoolSchool of Behavioural, Cognitive and Social Sciencesen
local.profile.emailthansto2@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.identifier.epublicationsrecordpes:6807en
local.publisher.placeGermanyen
local.format.startpage1031en
local.format.endpage1038en
local.peerreviewedYesen
local.identifier.volume43en
local.identifier.issue11en
local.contributor.lastnameClaytonen
local.contributor.lastnameHanstocken
local.contributor.lastnameHirnethen
local.contributor.lastnameKableen
local.contributor.lastnameGargen
local.contributor.lastnameHazellen
dc.identifier.staffune-id:thansto2en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:7042en
dc.identifier.academiclevelAcademicen
local.title.maintitleLong-Chain Omega-3 Polyunsaturated Fatty Acids in the Blood of Children and Adolescents with Juvenile Bipolar Disorderen
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorClayton, EHen
local.search.authorHanstock, Tanyaen
local.search.authorHirneth, SJen
local.search.authorKable, CJen
local.search.authorGarg, MLen
local.search.authorHazell, PLen
local.uneassociationUnknownen
local.identifier.wosid000260526200006en
local.year.published2008en
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