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https://hdl.handle.net/1959.11/6717
Title: | Selective transport of IgE into ovine mammary secretions | Contributor(s): | Hine, BC (author); Hunt, PW (author); Beasley, AM (author); Windon, RG (author); Glover, Stephen (author)![]() |
Publication Date: | 2010 | DOI: | 10.1016/j.rvsc.2010.02.010 | Handle Link: | https://hdl.handle.net/1959.11/6717 | Abstract: | Immunoglobulin (Ig) E is actively transported into ovine colostrum. Here we examine the degree of selectivity and the mechanism by which this transfer occurs in sheep. Results indicate that during colostrogenesis in sheep, transfer of immunoglobulins was most selective for IgG1 and IgA followed by IgE, IgM and IgG2. In milk, selectivity was greatest for IgA, followed by IgM, IgE, IgG1 and IgG2. The neonatal Fc receptor (FcRn) and poly immunoglobulin receptor (pIgR) mediate the transport of IgG1 and IgA across the ovine mammary epithelium respectively. In primates and rodents, the low-affinity IgE receptor, FcεRII, functions to transport IgE across the intestinal epithelium. We therefore investigated the expression of the low-affinity IgE receptor (CD23), pIgR and FcRn transcripts in the ovine mammary gland. The expression profiles of FcRn, pIgR and CD23 mRNA reflected concentrations of their Ig ligands in mammary secretions. These findings suggest a role for CD23 in transport of IgE across the mammary epithelium of sheep. | Publication Type: | Journal Article | Source of Publication: | Research in Veterinary Science, 89(2), p. 184-190 | Publisher: | Elsevier Ltd | Place of Publication: | United Kingdom | ISSN: | 1532-2661 0034-5288 |
Fields of Research (FoR) 2008: | 060602 Animal Physiology - Cell 060110 Receptors and Membrane Biology 070705 Veterinary Immunology |
Socio-Economic Objective (SEO) 2008: | 830507 Unprocessed or Minimally Processed Milk | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
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Appears in Collections: | Journal Article |
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