Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/6717
Title: Selective transport of IgE into ovine mammary secretions
Contributor(s): Hine, BC (author); Hunt, PW (author); Beasley, AM (author); Windon, RG (author); Glover, Stephen  (author)orcid ; Colditz, Ian  (author)
Publication Date: 2010
DOI: 10.1016/j.rvsc.2010.02.010
Handle Link: https://hdl.handle.net/1959.11/6717
Abstract: Immunoglobulin (Ig) E is actively transported into ovine colostrum. Here we examine the degree of selectivity and the mechanism by which this transfer occurs in sheep. Results indicate that during colostrogenesis in sheep, transfer of immunoglobulins was most selective for IgG1 and IgA followed by IgE, IgM and IgG2. In milk, selectivity was greatest for IgA, followed by IgM, IgE, IgG1 and IgG2. The neonatal Fc receptor (FcRn) and poly immunoglobulin receptor (pIgR) mediate the transport of IgG1 and IgA across the ovine mammary epithelium respectively. In primates and rodents, the low-affinity IgE receptor, FcεRII, functions to transport IgE across the intestinal epithelium. We therefore investigated the expression of the low-affinity IgE receptor (CD23), pIgR and FcRn transcripts in the ovine mammary gland. The expression profiles of FcRn, pIgR and CD23 mRNA reflected concentrations of their Ig ligands in mammary secretions. These findings suggest a role for CD23 in transport of IgE across the mammary epithelium of sheep.
Publication Type: Journal Article
Source of Publication: Research in Veterinary Science, 89(2), p. 184-190
Publisher: Elsevier Ltd
Place of Publication: United Kingdom
ISSN: 1532-2661
0034-5288
Fields of Research (FoR) 2008: 060602 Animal Physiology - Cell
060110 Receptors and Membrane Biology
070705 Veterinary Immunology
Socio-Economic Objective (SEO) 2008: 830507 Unprocessed or Minimally Processed Milk
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

Files in This Item:
3 files
File Description SizeFormat 
Show full item record

SCOPUSTM   
Citations

9
checked on Jan 20, 2024

Page view(s)

956
checked on Mar 9, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.