Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

2018

Théry, Clotilde

Witwer, Kenneth W

Aikawa, Elena

Alcaraz, Maria Jose

Anderson, Johnathon D

Andriantsitohaina, Ramaroson

Antoniou, Anna

Arab, Tanina

Archer, Fabienne

Atkin-Smith, Georgia K

Ayre, D Craig

Bach, Jean-Marie

Bachurski, Daniel

Baharvand, Hossein

Balaj, Leonora

Baldacchino, Shawn

Bauer, Natalie N

Baxter, Amy A

Bebawy, Mary

Beckham, Carla

Zavec, Apolonija Bedina

Benmoussa, Abderrahim

Berardi, Anna C

Bergese, Paolo

Bielska, Ewa

Blenkiron, Cherie

Bobis-Wozowicz, Sylwia

Boilard, Eric

Boireau, Wilfrid

Bongiovanni, Antonella

Borràs, Francesc E

Bosch, Steffi

Boulanger, Chantal M

Breakefield, Xandra

Breglio, Andrew M

Brennan, Meadhbh Á

Brigstock, David R

Brisson, Alain

Broekman, Marike LD

Bromberg, Jacqueline F

Bryl-Górecka, Paulina

Buch, Shilpa

Buck, Amy H

Burger, Dylan

Busatto, Sara

Buschmann, Dominik

Bussolati, Benedetta

Buzás, Edit I

Byrd, James Bryan

Camussi, Giovanni

Carter, David Rf

Caruso, Sarah

Chamley, Lawrence W

Chang, Yu-Ting

Chaudhuri, Amrita Datta

Chen, Chihchen

Chen, Shuai

Cheng, Lesley

Chin, Andrew R

Clayton, Aled

Clerici, Stefano P

Cocks, Alex

Cocucci, Emanuele

Coffey, Robert J

Cordeiro-da-Silva, Anabela

Couch, Yvonne

Coumans, Frank AW

Coyle, Beth

Crescitelli, Rossella

Criado, Miria Ferreira

D’Souza-Schorey, Crislyn

Das, Saumya

Candia, Paola de

Santana, Eliezer F De

Wever, Olivier De

Portillo, Hernando A Del

Demaret, Tanguy

Deville, Sarah

Devitt, Andrew

Dhondt, Bert

Vizio, Dolores Di

Dieterich, Lothar C

Dolo, Vincenza

Rubio, Ana Paula Dominguez

Dominici, Massimo

Dourado, Mauricio R

Driedonks, Tom Ap

Duarte, Filipe V

Duncan, Heather M

Eichenberger, Ramon M

Ekström, Karin

Andaloussi, Samir El

Elie-Caille, Celine

Erdbrügger, Uta

Falcón-Pérez, Juan M

Fatima, Farah

Fish, Jason E

Flores-Bellver, Miguel

Försönits, András

Frelet-Barrand, Annie

Fricke, Fabia

Fuhrmann, Gregor

Gabrielsson, Susanne

Gámez-Valero, Ana

Gardiner, Chris

Gärtner, Kathrin

Gaudin, Raphael

Gho, Yong Song

Giebel, Bernd

Gilbert, Caroline

Gimona, Mario

Giusti, Ilaria

Goberdhan, Deborah CI

Görgens, André

Gorski, Sharon M

Greening, David W

Gross, Julia Christina

Gualerzi, Alice

Gupta, Gopal N

Gustafson, Dakota

Handberg, Aase

Haraszti, Reka A

Harrison, Paul

Hegyesi, Hargita

Hendrix, An

Hill, Andrew F

Hochberg, Fred H

Hoffmann, Karl F

Holder, Beth

Holthofer, Harry

Hosseinkhani, Baharak

Hu, Guoku

Huang, Yiyao

Huber, Veronica

Hunt, Stuart

Ibrahim, Ahmed Gamal-Eldin

Ikezu, Tsuneya

Inal, Jameel M

Isin, Mustafa

Ivanova, Alena

Jackson, Hannah K

Jacobsen, Soren

Jay, Steven M

Jayachandran, Muthuvel

Jenster, Guido

Jiang, Lanzhou

Johnson, Suzanne M

Jones, Jennifer C

Jong, Ambrose

Jovanovic-Talisman, Tijana

Jung, Stephanie

Kalluri, Raghu

Kano, Shin-Ichi

Kaur, Sukhbir

Kawamura, Yumi

Keller, Evan T

Khamari, Delaram

Khomyakova, Elena

Khvorova, Anastasia

Kierulf, Peter

Kim, Kwang Pyo

Kislinger, Thomas

Klingeborn, Mikael

Klinke, II David J

Kornek, Miroslaw

Kosanović, Maja M

Ferenc Kovács, Árpád

Krämer-Albers, Eva-Maria

Krasemann, Susanne

Krause, Mirja

Kurochkin, Igor V

Kusuma, Gina D

Kuypers, Sören

Laitinen, Saara

Langevin, Scott M

Languino, Lucia R

Lannigan, Joanne

Lässer, Cecilia

Laurent, Louise C

Lavieu, Gregory

Lázaro-Ibáñez, Elisa

Lay, Soazig Le

Lee, Myung-Shin

Lee, Yi Xin Fiona

Lemos, Debora S

Lenassi, Metka

Leszczynska, Aleksandra

Li, Isaac TS

Liao, Ke

Libregts, Sten F

Ligeti, Erzsebet

Lim, Rebecca

Lim, Sai Kiang

Linē, Aija

Linnemannstöns, Karen

Llorente, Alicia

Lombard, Catherine A

Lorenowicz, Magdalena J

Lörincz, Ákos M

Lötvall, Jan

Lovett, Jason

Lowry, Michelle C

Loyer, Xavier

Lu, Quan

Lukomska, Barbara

Lunavat, Taral R

Maas, Sybren LN

Malhi, Harmeet

Marcilla, Antonio

Mariani, Jacopo

Mariscal, Javier

Martens-Uzunova, Elena S

Martin-Jaular, Lorena

Martinez, M Carmen

Martins, Vilma Regina

Mathieu, Mathilde

Mathivanan, Suresh

Maugeri, Marco

McGinnis, Lynda K

McVey, Mark J

Meckes, David G

Meehan, Katie L

Mertens, Inge

Minciacchi, Valentina R

Möller, Andreas

Jørgensen, Malene Møller

Morales-Kastresana, Aizea

Morhayim, Jess

Mullier, François

Muraca, Maurizio

Musante, Luca

Mussack, Veronika

Muth, Dillon C

Myburgh, Kathryn H

Najrana, Tanbir

Nawaz, Muhammad

Nazarenko, Irina

Nejsum, Peter

Neri, Christian

Neri, Tommaso

Nieuwland, Rienk

Nimrichter, Leonardo

Nolan, John P

Nm Nolte-'t Hoen, Esther

Hooten, Nicole Noren

O'Driscoll, Lorraine

O'Grady, Tina

O'Loghlen, Ana

Ochiya, Takahiro

Olivier, Martin

Ortiz, Alberto

Ortiz, Luis A

Osteikoetxea, Xabier

Østergaard, Ole

Ostrowski, Matias

Park, Jaesung

Pegtel, D Michiel

Peinado, Hector

Perut, Francesca

Pfaffl, Michael W

Phinney, Donald G

Pieters, Bartijn Ch

Pink, Ryan C

Pisetsky, David S

Strandmann, Elke Pogge von

Polakovicova, Iva

Poon, Ivan Kh

Powell, Bonita H

Prada, Ilaria

Pulliam, Lynn

Quesenberry, Peter

Radeghieri, Annalisa

Raffai, Robert L

Raimondo, Stefania

Rak, Janusz

Ramirez, Marcel I

Raposo, Graça

Rayyan, Morsi S

Regev-Rudzki, Neta

Ricklefs, Franz L

Robbins, Paul D

Roberts, David D

Rodrigues, Silvia C

Rohde, Eva

Rome, Sophie

Rouschop, Kasper Ma

Rughetti, Aurelia

Russell, Ashley E

Saá, Paula

Sahoo, Susmita

Salas-Huenuleo, Edison

Sánchez, Catherine

Saugstad, Julie A

Saul, Meike J

Schiffelers, Raymond M

Schneider, Raphael

Schøyen, Tine Hiorth

Scott, Aaron

Shahaj, Eriomina

Sharma, Shivani

Shatnyeva, Olga

Shekari, Faezeh

Shelke, Ganesh Vilas

Shetty, Ashok K

Shiba, Kiyotaka

Siljander, Pia R-M

Silva, Andreia M

Skowronek, Agata

Snyder, Orman L

Soares, Rodrigo Pedro

Sódar, Barbara W

Soekmadji, Carolina

Sotillo, Javier

Stahl, Philip D

Stoorvogel, Willem

Stott, Shannon L

Strasser, Erwin F

Swift, Simon

Tahara, Hidetoshi

Tewari, Muneesh

Timms, Kate

Tiwari, Swasti

Tixeira, Rochelle

Tkach, Mercedes

Toh, Wei Seong

Tomasini, Richard

Torrecilhas, Ana Claudia

Tosar, Juan Pablo

Toxavidis, Vasilis

Urbanelli, Lorena

Vader, Pieter

Balkom, Bas Wm van

Grein, Susanne G van der

Deun, Jan Van

Herwijnen, Martijn Jc van

Keuren-Jensen, Kendall Van

Niel, Guillaume van

Royen, Martin E van

Wijnen, Andre J van

Vasconcelos, M Helena

Vechetti Jr, Ivan J

Veit, Tiago D

Vella, Laura J

Velot, Émilie

Verweij, Frederik J

Vestad, Beate

Viñas, Jose L

Visnovitz, Tamás

Vukman, Krisztina V

Wahlgren, Jessica

Watson, Dionysios C

Wauben, Marca Hm

Weaver, Alissa

Webber, Jason P

Weber, Viktoria

Wehman, Ann M

Weiss, Daniel J

Welsh, Joshua A

Wendt, Sebastian

Wheelock, Asa M

Wiener, Zoltán

Witte, Leonie

Wolfram, Joy

Xagorari, Angeliki

Xander, Patricia

Xu, Jing

Yan, Xiaomei

Yáñez-Mó, María

Yin, Hang

Yuana, Yuana

Zappulli, Valentina

Zarubova, Jana

Žėkas, Vytautas

Zhang, Jian-Ye

Zhao, Zezhou

Zheng, Lei

Zheutlin, Alexander R

Zickler, Antje M

Zimmermann, Pascale

Zivkovic, Angela M

Zocco, Davide

Zuba-Surma, Ewa K

Journal Article

en

Publication

John Wiley & Sons Ltd

United Kingdom

10.1080/20013078.2018.1535750

une:1959.11/62753

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for ExtracellularVesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that as cribinga specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. TheMISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

link

Journal of Extracellular Vesicles, 7(1), p. 1-43

2001-3078

1

43

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