Plasmablast Recruitment to the Ruminant Mammary Gland

Title
Plasmablast Recruitment to the Ruminant Mammary Gland
Publication Date
2008
Author(s)
Hine, Bradley Charles
Glover, Stephen
( supervisor )
OrcID: https://orcid.org/0000-0002-9344-8669
Email: sglover@une.edu.au
UNE Id une-id:sglover
Colditz, Ian
Type of document
Thesis Doctoral
Language
en
Entity Type
Publication
UNE publication id
une:6416
Abstract
Antibodies derived from ruminant mammary secretion can be used prophylactically to protect humans against disease. Although ruminant colostrum is a rich source of antibodies, colostrum is produced only for a short time, whereas milk, which is produced over extended periods, contains extremely low concentrations of antibodies. Therefore the aim of this project was to investigate underlying biological principles that could be employed to develop strategies aimed at enhancing antibody levels in ruminant milk while maintaining normal milk production. To address this aim, it was proposed that increasing the numbers of antibody secreting cells (ASCs) resident in the mammary gland during the lactation period would lead to enhanced local antibody production and in turn increased amounts of antibody in milk.
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