Machine learning and Artificial Intelligence have grown significant attention from industry and academia during the past decade. The key reason behind interest is such technologies capabilities to revolutionize human life since they seamlessly integrate classical networks, networked objects and people to create more efficient environments. In this paper, the Knowledge Representation technique of Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA) is applied to facilitate Machine Learning. For effective and efficient decision-making in Machine Learning, the environment's own experience is captured, stored and reused using the DDNA technique. The proposed approach is implemented on practical test cases like a Chatbot. Decisional DNA gathers explicit experiential knowledge based on formal decision events and uses this knowledge to support decision-making processes. The experimental test and results of the presented implementation of Decisional DNA Chatbot case studies support it as a technology that can improve and be applied to the technology, enhancing intelligence by predicting capabilities and facilitating knowledge engineering processes.