Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/6163
Title: Effect of the Accuracy of an Estimated QTL Effect on Response to Marker-Assisted Selection
Contributor(s): Moghaddar, Nasir  (author); Van Der Werf, Julius H  (author)orcid 
Publication Date: 2009
Handle Link: https://hdl.handle.net/1959.11/6163
Abstract: The effect of the accuracy of estimated QTL effects on relative efficiency of marker-assisted selection (MAS) to non-MAS was investigated in a simulation study in a single trait selection scheme under variable heritability, different QTL effect and different initial QTL allele frequencies. The results showed that the probability of realized MAS response being less than expected response increased with higher standard error associated with an estimated QTL effect. This probability was significantly higher when a high standard error was associated with large QTL effects in lower QTL allele frequencies and/or lower heritability. The MAS responses could be equal or even less than non-MAS when the QTL variance from an inaccurate QTL effect constitutes a considerable proportion of overall genetic variance. This study showed that incorporating prior information about the QTL in a Bayesian approach can effectively remedy the problem of over prediction of MAS response.
Publication Type: Conference Publication
Conference Name: 18th Conference of the Association for the Advancement of Animal Breeding and Genetics, Barossa Valley, Australia, 27th September - 2nd October, 2009
Conference Details: 18th Conference of the Association for the Advancement of Animal Breeding and Genetics, Barossa Valley, Australia, 27th September - 2nd October, 2009
Source of Publication: Proceedings of the 18th Conference of the Association for the Advancement of Animal Breeding and Genetics: Matching Genetics and Environment - a New Look at an Old Topic, v.18, p. 564-567
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Taringa, Australia
ISSN: 1328-3227
Field of Research (FOR): 070201 Animal Breeding
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://www.aaabg.org/proceedings18/files/moghaddar564.pdf
http://aaabg.org/aaabg18/
http://trove.nla.gov.au/work/36420775
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