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Title: Therapeutic prospects of microRNAs in cancer treatment through nanotechnology
Contributor(s): Awasthi, Rajendra (author); Rathbone, Michael John (author); Hansbro, Philip Michael (author); Bebawy, Mary  (author)orcid ; Dua, Kamal (author)
Publication Date: 2018
Early Online Version: 2017-11-28
DOI: 10.1007/s13346-017-0440-1
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MicroRNAs (miRNAs) represent a new class of diagnostic and prognostic biomarker as well as new therapeutic targets in cancer therapy. miRNAs are gaining significant interest due to extensive advancements in knowledge since their discovery and, more recently, their translational application as therapeutic moieties and targets in the management of disease. miRNAs used in the treatment of cancer would position them as a new class of emerging therapeutic agents. Indeed, numerous candidate miRNAs have been identified as having therapeutic application in the treatment of cancer, but there is still much to learn about how to transform these into effective, patient-compliant, and targeted drug delivery systems. In this mini review, we discuss the utility and potential of nanotechnology in miRNA formulation and delivery with particular emphasis on cancer, including their role in conferring multidrug resistance and metastatic capacity. This review benefits both the formulation and biological scientists in understanding and exploring the new vistas of miRNA delivery using nanotechnology in the cancer clinically.

Publication Type: Journal Article
Source of Publication: Drug Delivery and Translational Research, v.8, p. 97-110
Publisher: Springer
Place of Publication: Germany
ISSN: 2190-3948
Fields of Research (FoR) 2020: 3208 Medical physiology
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

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