Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/61227
Title: Curcumin-Loaded Niosomes Downregulate mRNA Expression of Pro-Inflammatory Markers Involved in Asthma: An In Vitro Study
Contributor(s): Wong, Jin-Ying (author); Yin Ng, Zhao (author); Mehta, Meenu (author); Dhar Shukla, Shakti (author); Panneerselvam, Jithendra (author); Madheswaran, Thiagarajan (author); Gupta, Gaurav (author); Negi, Poonam (author); Kumar, Pradeep (author); Pillay, Viness (author); Hsu, Alan (author); Hansbro, Nicole G (author); Wark, Peter (author); Bebawy, Mary  (author)orcid ; Hansbro, Philip Michael (author); Dua, Kamal (author); Kumar Chellappan, Dinesh (author)
Publication Date: 2020
DOI: 10.2217/nnm-2020-0260
Handle Link: https://hdl.handle.net/1959.11/61227
Abstract: 

Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-α in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.

Publication Type: Journal Article
Source of Publication: Nanomedicine, 15(30), p. 2955-2970
Publisher: Future Medicine Ltd
Place of Publication: United Kingdom
ISSN: 1748-6963
1743-5889
Fields of Research (FoR) 2020: 3208 Medical physiology
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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