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Title: Targeting respiratory diseases using miRNA inhibitor based nanotherapeutics: Current status and future perspectives
Contributor(s): Mehta, Meenu (author); Satija, Saurabh (author); Paudel, Keshav R (author); Malyla, Vamshikrishna (author); Kumar Kannaujiya, Vinod (author); Kumar Chellappan, Dinesh (author); Bebawy, Mary  (author)orcid ; Hansbro, Philip M (author); Wich, Peter R (author); Dua, Kamal (author)
Publication Date: 2021-01
DOI: 10.1016/j.nano.2020.102303
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MicroRNAs (miRNAs) play a fundamental role in the developmental and physiological processes that occur in both animals and plants. AntagomiRs are synthetic antagonists of miRNA, which prevent the target mRNA from suppression. Therapeutic approaches that modulate miRNAs have immense potential in the treatment of chronic respiratory disorders. However, the successful delivery of miRNAs/antagomiRs to the lungs remains a major challenge in clinical applications. A range of materials, namely, polymer nanoparticles, lipid nanocapsules and inorganic nanoparticles, has shown promising results for intracellular delivery of miRNA in chronic respiratory disorders. This review discusses the current understanding of miRNA biology, the biological roles of antagomiRs in chronic respiratory disease and the recent advances in the therapeutic utilization of antagomiRs as disease biomarkers. Furthermore our review provides a common platform to debate on the nature of antagomiRs and also addresses the viewpoint on the new generation of delivery systems that target antagomiRs in respiratory diseases.

Publication Type: Journal Article
Source of Publication: Nanomedicine: Nanotechnology, Biology and Medicine, v.31, p. 1-17
Publisher: Elsevier Inc
Place of Publication: United States of America
ISSN: 1549-9642
Fields of Research (FoR) 2020: 3208 Medical physiology
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

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