Genetic variation in residual feed intake is associated with body composition, behavior, rumen, heat production, hematology, and immune competence traits in Angus cattle

Abstract

<p>This experiment was to evaluate a suite of biological traits likely to be associated with genetic variation in residual feed intake (<b>RFI</b>) in Angus cattle. Twenty nine steers and 30 heifers bred to be divergent in postweaning RFI (<b>RFIp</b>) and that differed in midparent RFIp -EBV (<b>RFIp-EBVmp</b>) by more than 2 kg DMI/d were used in this study. A 1-unit (1 kg DM/d) decrease in RFI_p -EBV_mp was accompanied by a 0.08 kg (SE = 0.03; <i>P</i> < 0.05) increase in ADG, a 0.58 kg/d (0.17; <i>P</i> < 0.01) decrease in DMI, a 0.89 kg/kg (0.22; <i>P</i> < 0.001) decrease in FCR, and a 0.62 kg/d (0.12; <i>P</i> < 0.001) decrease in feedlot RFI (<b>RFIf</b>). Ultrasonically scanned depths of subcutaneous fat at the rib and rump sites, measured at the start and end of the RFI test, all had strong positive correlations with RFI_p -EBV_mp, DMI, and RFI_f (all r values ≥0.5 and <i>P</i> < 0.001). Variation in RFI_p -EBV_mp was significantly correlated (<i>P</i> < 0.05) with flight speed (<i>r</i> = −0.32), number of visits to feed bins (<i>r</i> = 0.45), and visits to exhaled-emission monitors (<i>r</i> = −0.27), as well as the concentrations of propionate (<i>r</i> = −0.32) and valerate (<i>r</i> = −0.31) in rumen fluid, white blood cell (<i>r</i> = −0.51), lymphocyte (<i>r</i> = −0.43), and neutrophil (<i>r</i> = −0.31) counts in blood. RFI_p -EBV_mp was also correlated with the cellular immune response to vaccination (<i>r</i> = 0.25; <i>P</i> < 0.1) and heat production in fasted cattle (<i>r</i> = −0.46; <i>P</i> < 0.001). Traits that explained significant variation (<i>P</i> < 0.05) in DMI over the RFI test were midtest metabolic-BW (44.7%), rib fat depth at the end of test (an additional 18%), number of feeder visits (additional 5.7%), apparent digestibility of the ration by animals (additional 2.4%) and white blood-cell count (2.1%), and the cellular immune response to vaccine injection (additional 1.1%; <i>P</i> < 0.1), leaving ~23% of the variation in DMI unexplained. The same traits (BW excluded) explained 33%, 12%, 3.6%, 3.7%, and 3.1%, and together explained 57% of the variation in RFI_f. This experiment showed that genetic variation in RFI was accompanied by variation in estimated body composition, behavior, rumen, fasted heat production, hematology, and immune competence traits, and that variation in feedlot DMI and RFI_f was due to differences in BW, scanned fatness, and many other factors in these cattle fed ad libitum and able to display any innate differences in appetite, temperament, feeding behavior, and activity</p>