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Title: An Initial Exploration of 'in vivo' Hair Cortisol Responses to a Brief Pain Stressor: Latency, Localization and Independence Effects
Contributor(s): Sharpley, Christopher  (author)orcid ; Kauter, Kathleen (author); McFarlane, James R (author)orcid 
Publication Date: 2009
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Abstract: Cortisol is secreted by the central hypothalamo-pituitary-adrenal axis and affects many target organs and tissues, particularly in response to stressor demands and infection. Recent data reporting cortisol synthesis in hair follicles have shown the existence of a parallel "peripheral" HPA-axis. However, although there is evidence from 'in vitro' studies and single-observation comparisons between groups that cortisol from hair follicles reflects endocrine changes associated with stressor demands, there are no reports to date of repeated measurements of 'in vivo' cortisol responsivity in hair to transitory stressors. This issue was investigated with three males who underwent 1 min cold pressor test (CP). Cortisol response in hair to stressor demand appears to be (a) swift but transitory, (b) localized to the site of the demand and (c) independent of central HPA-axis activity.
Publication Type: Journal Article
Source of Publication: Physiological Research, 58(5), p. 757-761
Publisher: Fyziologicky Ustav, Akademie Ved Ceske Republiky [Institute of Physiology, Academy of Sciences of the Czech Republic]
Place of Publication: Prague, Czech Republic
ISSN: 0862-8408
Field of Research (FOR): 060699 Physiology not elsewhere classified
060604 Comparative Physiology
060101 Analytical Biochemistry
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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