Ring-Expansion Reactions of the Biomass Derivative Cyrene via Enamine Dihalocyclopropanation

Title
Ring-Expansion Reactions of the Biomass Derivative Cyrene via Enamine Dihalocyclopropanation
Publication Date
2024-03-01
Author(s)
Puschnig, Johannes
Greatrex, Ben W
( author )
OrcID: https://orcid.org/0000-0002-0356-4966
Email: bgreatre@une.edu.au
UNE Id une-id:bgreatre
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Place of publication
Germany
DOI
10.1002/ejoc.202400031
UNE publication id
une:1959.11/59165
Abstract

A ring-expansion process for the biomass derivative Cyrene obtained from levoglucosenone has been developed using gem-dihalocyclopropanes as intermediates. The process involves conversion of Cyrene to an enamine, reaction with an in situ generated dihalocarbene, and then ring-opening. Competition between endocyclic and exocyclic olefinic products was switchable using solvent and temperature, and ringexpanded alkenyl halides were obtained in 50–64% yield from Cyrene. Under extended heating, dehalogenation occurred giving homologated levoglucosenone in 25% overall yield from Cyrene in 3 steps.

Link
Citation
European Journal of Organic Chemistry, 27(9), p. 1-5
ISSN
1099-0690
1434-193X
Start page
1
End page
5
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International

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