Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/58544
Title: Biomolecular engineering of virus-like particles aided by computational chemistry methods
Contributor(s): Zhang, Lin (author); Lua, Linda H L (author); Middelberg, Anton P J (author); Sun, Yan (author); Connors, Natalie K  (author)orcid 
Publication Date: 2015
DOI: 10.1039/c5cs00526d
Handle Link: https://hdl.handle.net/1959.11/58544
Abstract: 

Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both innate and adaptive immune responses, due to their particulate structure enabling uptake by antigen presenting cells. These characteristics have led to successful development of VLP-vaccine products, and will ensure their vast potential in years to come. Future success of VLP therapeutic products will be determined by advances in their bioengineering, and also by the development of tools to design for their stability, function and application. This review focuses on approaches for VLP assembly in controlled chemical environments in vivo and in vitro, and the application of computational tools for improved chemical sequence design, and fundamental understanding of assembly.

Publication Type: Journal Article
Source of Publication: Chemical Society Reviews, v.44, p. 8608-8618
Publisher: Royal Society of Chemistry
Place of Publication: United Kingdom
ISSN: 1460-4744
0306-0012
Fields of Research (FoR) 2020: 3003 Animal production
Socio-Economic Objective (SEO) 2020: tbd
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article

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