Weeds have a significant impact on vegetable production worldwide. These intensive cropping systems feature frequent tillage, fertilization and irrigation, providing ideal growing conditions for crops as well as certain weeds. Integrated weed management (IWM) can reduce reliance on herbicides by encouraging a systems approach to weed management. Using insights from global research and industry literature, we investigated the effectiveness of prevailing weed control methods, and evaluated emerging management practices and technologies for ongoing research and adoption. Weed control relies primarily on a relatively narrow range of herbicides as well as frequent tillage. Herbicides have negative impacts on soil, water and human health, while tillage impacts soil quality and function. Intensive cropping on smaller plots facilitates IWM, relying on multiple strategies including hand weeding, mulches, cover crops and cultural methods (e.g., crop rotations, timing). New herbicide options are suggested as an industry priority but are constrained by the lack of new chemistry and potential herbicide resistance. Refinement and adoption of non-herbicide and emerging precision control methods into farm IWM in vegetables is more likely to be sustainable. This review is relevant to advanced vegetable production systems globally, but also to smallholder vegetable production in developing economies.