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Title: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory
Contributor(s): Wray, Naomi R (author); Coventry, William Luya  (author)orcid ; James, Michael R (author); Montgomery, Grant W (author); Eaves, Lindon J (author); Martin, Nicholas G (author)
Publication Date: 2008
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Abstract: We examine the interaction between stressful life events (SLE) and genotypes for the length polymorphism of the serotonin receptor gene (SHTTLPR) on risk of depression. We hypothesize that if the interaction is real, monozygotic twin pairs (MZT) homozygous for the short allele (SS) will have a greater within pair variance In depression measures than MZT homozygous for the long allele (LL), as a reflection of their increased sensitivity to unknown environmental risk factors. Telephone interviews were used to assess symptoms of depression and suicidality on 824 MZT. Rather than using the interview items to calculate sum scores or allocate diagnostic classes we use Item Response Theory to model the contribution of each item to each individual's underlying liability to depression. SLE were also measured on the MZT assessed by mailed questionnaire on average 3.8 years previously, and these were used in follow-up analyses. We find no evidence for significant differences in within pair variance between 5HTTLPR genotypic classes and so can provide no support for interaction between these genotypes and the environment. The use of MZT provides a novel framework for examining genotype X environment interaction in the absence of measures on SLE.
Publication Type: Book Chapter
Source of Publication: Genetic Effects on Environmental Vulnerability to Disease, p. 48-67
Publisher: John Wiley & Sons Ltd
Place of Publication: Chichester, United Kingdom
ISBN: 047077780X
Field of Research (FOR): 060499 Genetics not elsewhere classified
Socio-Economic Outcome Codes: 920410 Mental Health
HERDC Category Description: B1 Chapter in a Scholarly Book
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Series Name: Novartis Foundation symposia
Series Number : 293
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Appears in Collections:Book Chapter

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