Dynamic Studies Of Lung Fluid Clearance With Phase Contrast Imaging

Author(s)
Kitchen, Marcus J
Lewis, Rob A
Yagi, Naoto
Uesugi, Kentaro
Hooper, Stuart B
Wallace, Megan J
Siu, Karen K W
Williams, Ivan
Irvine, Sarah C
Morgan, Michael J
Paganin, David M
Pavlov, Konstantin M
Publication Date
2007
Abstract
Clearance of liquid from the airways at birth is a poorly understood process, partly due to the difficulties of observing and measuring the distribution of air within the lung. Imaging dynamic processes within the lung in vivo with high contrast and spatial resolution is therefore a major challenge. However, phase contrast X-ray imaging is able to exploit inhaled air as a contrast agent, rendering the lungs of small animals visible due to the large changes in the refractive index at air/tissue interfaces. In concert with the high spatial resolution afforded by X-ray imaging systems (<100 µm), propagation-based phase contrast imaging is ideal for studying lung development. To this end we have utilized intense, monochromatic synchrotron radiation, together with a fast readout CCD camera, to study fluid clearance from the lungs of rabbit pups at birth. Local rates of fluid clearance have been measured from the dynamic sequences using a single image phase retrieval algorithm. ©2007 American Institute of Physics
Citation
Ninth International Conference on Synchrotron Radiation Instrumentation, v.879, p. 1903-1907
ISBN
9780735403734
Link
Publisher
AIP Publishing LLC
Series
AIP Conference Proceedings
Title
Dynamic Studies Of Lung Fluid Clearance With Phase Contrast Imaging
Type of document
Conference Publication
Entity Type
Publication

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