Multi-trait genome wide association meta-analysis of body weight, carcase composition and eating quality traits in Australian sheep

Title
Multi-trait genome wide association meta-analysis of body weight, carcase composition and eating quality traits in Australian sheep
Publication Date
2023-07-26
Author(s)
Moghaddar, N
( author )
OrcID: https://orcid.org/0000-0002-3600-7752
Email: nmoghad4@une.edu.au
UNE Id une-id:nmoghad4
Swan, A A
( author )
OrcID: https://orcid.org/0000-0001-8048-3169
Email: aswan@une.edu.au
UNE Id une-id:aswan
Van Der Werf, J H J
( author )
OrcID: https://orcid.org/0000-0003-2512-1696
Email: jvanderw@une.edu.au
UNE Id une-id:jvanderw
Editor
Editor(s): Hatcher, Sue
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of publication
Armidale, Australia
UNE publication id
une:1959.11/56122
Abstract

The objective of this study was to perform a multi-trait meta-analysis of summary statistics of a single-trait genome-wide association study (GWAS) on 10 body weight, carcase composition and eating quality traits in Australian sheep. Meta-analysis was performed based on an approximate chisquared test according to estimated SNP effects and their associated standard errors obtained in a single-trait GWAS. Single-trait association testing was based on single-marker regression analysis in linear mixed models using imputed whole genome sequence data and between 2,707 and 135,022 adjusted phenotypes across the traits studied. Meta-analysis showed higher power of QTL detection compared to single trait GWAS, it confirmed the highly significant QTL regions in single-trait GWAS and revealed numerous pleiotropic QTLs on chromosomes 1, 3, 6, 8, 11, 16 and 18, affecting two or more traits. In total meta-analysis showed 4,823 SNPs in strong association with at least one trait (-Log P≥6.0) but did not show any new highly significant QTL regions across the traits.

Link
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.25, p. 270-273
ISSN
1328-3227
Start page
270
End page
273

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