Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/55943
Title: Network analysis of frontal lobe alpha asymmetry confirms the neurophysiological basis of four subtypes of depressive behavior
Contributor(s): Sharpley, Christopher F  (author)orcid ; Bitsika, Vicki  (author)orcid ; Arnold, Wayne M  (author)orcid ; Shadli, Shabah M  (author)orcid ; Jesulola, Emmanuel  (author); Agnew, Linda L  (author)orcid 
Publication Date: 2023-06-28
Open Access: Yes
DOI: 10.3389/fpsyt.2023.1194318
Handle Link: https://hdl.handle.net/1959.11/55943
Abstract: 

Introduction: Although depression is widespread carries a major disease burden, current treatments remain non-universally effective, arguably due to the heterogeneity of depression, and leading to the consideration of depressive "subtypes" or "depressive behavior subtypes." One such model of depressive behavior (DB) subtypes was investigated for its associations with frontal lobe asymmetry (FLA), using a different data analytic procedure than in previous research in this field.

Methods: 100 community volunteers (54 males, 46 females) aged between 18yr. and 75years (M=32.53yr., SD=14.13yr) completed the Zung Self-rating Depression Scale (SDS) and underwent 15min of eyes closed EEG resting data collection across 10 frontal lobe sites. DB subtypes were defined on the basis of previous research using the SDS, and alpha-wave (8-13Hz) data produced an index of FLA. Data were examined via network analysis.

Results: Several network analyses were conducted, producing two models of the association between DB subtypes and FLA, confirming unique neurophysiological profiles for each of the four DB subtypes.

Discussion: As well as providing a firm basis for using these DB subtypes in clinical settings, these findings provide a reasonable explanation for the inconsistency in previous FLA-depression research.

Publication Type: Journal Article
Source of Publication: Frontiers in Psychiatry, v.14, p. 1-10
Publisher: Frontiers Research Foundation
Place of Publication: Switzerland
ISSN: 1664-0640
Fields of Research (FoR) 2020: 320903 Central nervous system
Socio-Economic Objective (SEO) 2020: 200409 Mental health
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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