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Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/55423
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dc.contributor.authorLoh, Zen
dc.contributor.authorvan der Werf, J H Jen
dc.contributor.authorClark, Sen
dc.date.accessioned2023-07-25T06:04:14Z-
dc.date.available2023-07-25T06:04:14Z-
dc.date.issued2021-
dc.identifier.citationProceedings of the Association for the Advancement of Animal Breeding and Genetics, v.24, p. 208-211en
dc.identifier.issn1328-3227en
dc.identifier.urihttps://hdl.handle.net/1959.11/55423-
dc.description.abstractWhile genome-wide association study (GWAS) is an important tool for gene discovery for economic traits in livestock, its use of large numbers of genetic markers necessitates the use of multiple testing correction methods. Several of these methods have been suggested, but their optimality is not as well studied. The aim of this study is to present a deterministic algorithm to provide a framework for estimating the power and false positive rate (FPR) in a GWAS, and using these estimates to test the optimality of these correction method based on the Receiver Operating Characteristic (ROC) curve. This study suggests that both Bonferroni correction and Benjamini-Hochberg False Discovery Rate are overly conservative even if under the assumption of independence between markers.en
dc.languageenen
dc.publisherAssociation for the Advancement of Animal Breeding and Genetics (AAABG)en
dc.relation.ispartofProceedings of the Association for the Advancement of Animal Breeding and Geneticsen
dc.titleA deterministic algorithm for optimality of threshold in a GWAS experimenten
dc.typeConference Publicationen
dc.relation.conferenceAAABG 2021: 24th Conference of the Association for the Advancement of Animal Breeding and Geneticsen
dcterms.accessRightsGolden
local.contributor.firstnameZen
local.contributor.firstnameJ H Jen
local.contributor.firstnameSen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailjvanderw@une.edu.auen
local.profile.emailsclark37@une.edu.auen
local.output.categoryE1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.date.conference2nd - 4th November, 2021en
local.conference.placeOnline Eventen
local.publisher.placeArmidale, Australiaen
local.format.startpage208en
local.format.endpage211en
local.url.openhttp://www.aaabg.org/aaabghome/proceedings24.phpen
local.peerreviewedYesen
local.identifier.volume24en
local.access.fulltextYesen
local.contributor.lastnameLohen
local.contributor.lastnamevan der Werfen
local.contributor.lastnameClarken
dc.identifier.staffune-id:jvanderwen
dc.identifier.staffune-id:sclark37en
local.profile.orcid0000-0003-2512-1696en
local.profile.orcid0000-0001-8605-1738en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/55423en
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleA deterministic algorithm for optimality of threshold in a GWAS experimenten
local.output.categorydescriptionE1 Refereed Scholarly Conference Publicationen
local.conference.detailsAAABG 2021: 24th Conference of the Association for the Advancement of Animal Breeding and Genetics, Online Event, 2nd - 4th November, 2021en
local.search.authorLoh, Zen
local.search.authorvan der Werf, J H Jen
local.search.authorClark, Sen
local.uneassociationUnknownen
local.atsiresearchNoen
local.conference.venueOnline Eventen
local.sensitive.culturalNoen
local.year.published2021en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/754b5ac9-966a-4b92-bc35-feb9d206998aen
local.subject.for2020300305 Animal reproduction and breedingen
local.subject.for2020300302 Animal managementen
local.subject.for2020310509 Genomicsen
local.subject.seo2020100499 Livestock raising not elsewhere classifieden
local.subject.seo2020100699 Primary products from animals not elsewhere classifieden
local.subject.seo2020100499 Livestock raising not elsewhere classifieden
local.date.start2021-11-02-
local.date.end2021-11-04-
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
local.profile.affiliationtypeUnknownen
Appears in Collections:Conference Publication
School of Environmental and Rural Science
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