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Title: Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis
Contributor(s): Xu, Ying (author); Phu, Jack (author); Aung, Htein Linn (author); Hesam-Shariati, Negin (author); Keay, Lisa (author); Tully, Phillip J  (author)orcid ; Booth, Andrew (author); Anderson, Craig S (author); Anstey, Kaarin J (author); Peters, Ruth (author)
Publication Date: 2023
Early Online Version: 2023-03-15
Open Access: Yes
DOI: 10.1038/s41433-023-02481-4
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OBJECTIVE: We aim to quantify the co-existence of age-related macular degeneration (AMD), glaucoma, or diabetic retinopathy (DR) and cognitive impairment or dementia.

METHOD: MEDLINE, EMBASE, PsycINFO and CINAHL were searched (to June 2020). Observational studies reporting incidence or prevalence of AMD, glaucoma, or DR in people with cognitive impairment or dementia, and of cognitive impairment or dementia among people with AMD, glaucoma, or DR were included.

RESULTS: Fifty-six studies (57 reports) were included but marked by heterogeneities in the diagnostic criteria or definitions of the diseases, study design, and case mix. Few studies reported on the incidence. Evidence was sparse but consistent in individuals with mild cognitive impairment where 7.7% glaucoma prevalence was observed. Prevalence of AMD and DR among people with cognitive impairment ranged from 3.9% to 9.4% and from 11.4% to 70.1%, respectively. Prevalence of AMD and glaucoma among people with dementia ranged from 1.4 to 53% and from 0.2% to 25.9%, respectively. Prevalence of DR among people with dementia was 11%. Prevalence of cognitive impairment in people with AMD, glaucoma, and DR ranged from 8.4% to 52.4%, 12.3% to 90.2%, and 3.9% to 77.8%, respectively, and prevalence of dementia in people with AMD, glaucoma and DR ranged from 9.9% to 62.6%, 2.5% to 3.3% and was 12.5%, respectively.

CONCLUSIONS: Frequency of comorbid eye disease and cognitive impairment or dementia varied considerably. While more population-based estimations of the co-existence are needed, interdisciplinary collaboration might be helpful in the management of these conditions to meet healthcare needs of an ageing population.

Publication Type: Journal Article
Source of Publication: Eye, v.37, p. 3128-3136
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 1476-5454
Fields of Research (FoR) 2020: 321299 Ophthalmology and optometry not elsewhere classified
Socio-Economic Objective (SEO) 2020: 200199 Clinical health not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Psychology

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