Genome-wide association study for carcass traits in Hanwoo cattle using additional relatives' information of non-genotyped animals

Title
Genome-wide association study for carcass traits in Hanwoo cattle using additional relatives' information of non-genotyped animals
Publication Date
2022-12
Author(s)
Kim, Hyoun Ju
de las Heras-Saldana, Sara
( author )
OrcID: https://orcid.org/0000-0002-8665-6160
Email: sdelash2@une.edu.au
UNE Id une-id:sdelash2
Moghaddar, Nasir
( author )
OrcID: https://orcid.org/0000-0002-3600-7752
Email: nmoghad4@une.edu.au
UNE Id une-id:nmoghad4
Lee, Seung-Hwan
Lim, Dajeong
van der Werf, Julius H J
( author )
OrcID: https://orcid.org/0000-0003-2512-1696
Email: jvanderw@une.edu.au
UNE Id une-id:jvanderw
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Wiley-Blackwell Publishing Ltd
Place of publication
United Kingdom
DOI
10.1111/age.13251
UNE publication id
une:1959.11/53699
Abstract
The aim of this study was to find significant genomic regions associated with carcass traits in Hanwoo cattle and to compare the benefit of using additional information from non-genotyped animals. Imputed whole-genome sequence data were used along with phenotypic data on 13 715 genotyped animals as well as phenotypes of 440 284 non-genotyped animals that were offspring of 454 genotyped sires. For carcass weight, 15 083 SNPs in 33 QTL regions and 313 candidate genes were identified. We found 410 SNPs in 17 QTL regions containing 122 candidate genes for back fat thickness. In total, 656 SNPs in 19 QTLs with 137 candidate genes for eye muscle area and 79 SNPs in 12 QTL regions with 77 candidate genes were identified for marbling score. The most important candidate genes included ZFAT, TG, PLAG1, CHCHD7, and TOX for carcass weight and eye muscle area, NOG for back fat thickness, and EVOVL5 for marbling score. This study showed that the use of phenotypic records on non-genotyped progeny along with imputed whole-genome sequence data increased the power of detecting new significant genomic regions.
Link
Citation
Animal Genetics, 53(6), p. 863-866
ISSN
1365-2052
0268-9146
Pubmed ID
35993261
Start page
863
End page
866

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