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Title: Phytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementation
Contributor(s): Yu, Sung J (author); Bajagai, Yadav S (author); Petranyi, Friedrich (author); de las Heras-Saldana, Sara  (author)orcid ; Van, Thi Thu Hao (author); Stanley, Dragana (author)
Publication Date: 2022-10-18
Open Access: Yes
DOI: 10.3390/antibiotics11101428
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Fields of Research (FoR) 2020: 310904 Animal diet and nutrition
Socio-Economic Objective (SEO) 2020: 100411 Poultry
Abstract: Poultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures and continual vigilance in monitoring animal health parameters. Despite this vigilance, dealing with disease outbreaks is a part of farmers' routines. Phytogenic feed additives comprised of herbs, spices, essential oils, and oleoresins have potent antimicrobial and anti-inflammatory actions. Related studies are gaining substantial interest in human and animal health worldwide. In this study, a commercial blend phytogenic feed additive was supplemented to layers in an industrial free-range production system with 20,000 birds in both control and treatment groups. At the end of the trial, the ileum tissue was sampled for RNAseq transcriptomic analysis to study the host reaction to the supplement. Phytogenic supplement significantly inhibited four cholesterol-related pathways and reduced the Arteriosclerosis disease category towards improved cardiovascular health. The supplemented birds exhibited reduced disease susceptibility for 26 cancer categories with p-values in the range from 5.23 × 10−4 to 1.02 × 10−25. Major metabolic shifts in Lipid metabolism in combination with Carbohydrate metabolism have resulted in a decrease in the Obesity category, altering the ratio of fat and carbohydrate metabolism toward lower fat storage.
Publication Type: Journal Article
Source of Publication: Antibiotics, 11(10), p. 1-14
Publisher: MDPI AG
Place of Publication: Switzerland
ISSN: 2079-6382
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article

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