Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/53586
Title: Peripheral sensation and RIC inhibition: is diabetic peripheral neuropathy just the tip of the iceberg?
Contributor(s): Epps, Jacqueline A  (author)orcid ; Dieberg, Gudrun  (author)orcid ; Smart, Neil A  (author)orcid 
Publication Date: 2022-02
Open Access: Yes
Handle Link: https://hdl.handle.net/1959.11/53586
Open Access Link: http://www.conditionmed.org/Data/View/12885Open Access Link
Abstract: Remote ischemic conditioning (RIC) is a therapeutic intervention, known for reducing irreversible damage caused by ischemia-reperfusion injury. Demonstrating great promise in preclinical studies, this outcome has not been consistently reproduced in larger clinical studies. The diabetic state has shown a variable response to RIC. Diabetic sensorimotor polyneuropathy (DSPN) is one of the factors limiting the protective effects of RIC; this was first identified in the 2012 Jensen study. However, the presence of neuropathy or DSPN is still very rarely included in participant characteristics, despite widely accepted evidence that DSPN inhibits the protective effects of RIC. Even if it became standard practice to report the presence and type of neuropathy in RIC studies involving patients with diabetes, much more information is required about the inhibitory effects of DSPN on RIC. The extent of its impact needs to be determined. We argue that a failure to adequately identify peripheral sensory neuropathy, especially DSPN, in study participants may be an important but overlooked confounding factor in RIC research. This review aims to identify and address numerous overlooked questions regarding DSPN, its precursors and its subtypes, and their interactions with RIC. Finally, a series of recommendations are made with respect to RIC studies likely to involve participants with DSPN or similar peripheral sensory impairments, that may assist the transition to clinical practice.
Publication Type: Journal Article
Source of Publication: Conditioning Medicine, 5(1), p. 11-21
Publisher: Conditioning Medicine
Place of Publication: United States of America
ISSN: 2577-3240
Fields of Research (FoR) 2020: 320101 Cardiology (incl. cardiovascular diseases)
329999 Other biomedical and clinical sciences not elsewhere classified
Socio-Economic Objective (SEO) 2020: 200105 Treatment of human diseases and conditions
200199 Clinical health not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Publisher/associated links: http://www.conditionmed.org/Data/List/Archives
Appears in Collections:Journal Article
School of Rural Medicine
School of Science and Technology

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