Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/53302
Title: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
Contributor(s): Charlesworth, Brian (author); Goddard, Michael E (author); Meyer, Karin  (author)orcid ; Visscher, Peter M (author); Weir, Bruce S (author); Wray, Naomi R (author)
Publication Date: 2022-07-11
DOI: 10.1038/s41588-022-01103-1
Handle Link: https://hdl.handle.net/1959.11/53302
Abstract: The quantitative geneticist W. G. ('Bill') Hill, awardee of the 2018 Darwin Medal of the Royal Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 December 2021 at the age of 81 years. Here, we pay tribute to his multiple key scientific contributions, which span population and evolutionary genetics, animal and plant breeding and human genetics. We discuss his theoretical research on the role of linkage disequilibrium (LD) and mutational variance in the response to selection, the origin of the widely used LD metric r2 in genomic association studies, the genetic architecture of complex traits, the quantification of the variation in realized relationships given a pedigree relationship and much more. We demonstrate that basic theoretical research in quantitative and statistical genetics has led to profound insights into the genetics and evolution of complex traits and made predictions that were subsequently empirically validated, often decades later.
Publication Type: Journal Article
Grant Details: NHMRC/1113400
NHMRC/1173790
ARC/FL180100072
Source of Publication: Nature Genetics, 54(7), p. 934-939
Publisher: Nature Publishing Group
Place of Publication: United States of America
ISSN: 1546-1718
1061-4036
Fields of Research (FoR) 2020: 310207 Statistical and quantitative genetics
Socio-Economic Objective (SEO) 2020: 100499 Livestock raising not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Journal Article

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