QTL mapping in multiple families using logistic regression

Title
QTL mapping in multiple families using logistic regression
Publication Date
2009
Author(s)
Zhang, Yuandan
( author )
OrcID: https://orcid.org/0000-0002-1998-3313
Email: yzhang4@une.edu.au
UNE Id une-id:yzhang4
Tier, Bruce
Editor
Editor(s): Alex Safari, Bill Pattie, Barrie Restall
Type of document
Conference Publication
Language
en
Entity Type
Publication
Publisher
Association for the Advancement of Animal Breeding and Genetics (AAABG)
Place of publication
Armidale, Australia
UNE publication id
une:5361
Abstract
This study compares logistic regression (LR) with maximum likelihood (ML) methods for mapping quantitative trait loci (QTL) in multiple half-sib families under selective or full genotyping strategies, with various levels of marker informativeness and marker interval. In ideal conditions involving evenly located polymorphic markers and all individuals genotyped, both LR and ML methods showed a high power of detecting QTL and produced accurate estimates of QTL locations and effects. Under selective genotyping strategy, the power of ML is limited by regions with low information content. The LR method performed better than ML and is a straight-forward and robust method for this case.
Link
Citation
Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.18, p. 664-667
ISSN
1328-3227
ISBN
9780646521039
Start page
664
End page
667

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