Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/5229
Title: Identification of Differentially Expressed Transcripts in M. 'Longissmus Dorsi' With Divergent Marbling Phenotypes in Hanwoo (Korean Native Cattle)
Contributor(s): Lee, Seung Hwan (author); Gondro, Cedric (author)orcid ; Kim, NK (author); Lim, DJ (author); Shin, YH (author); Thompson, John (author); Gibson, John (author); Van Der Werf, Julius H (author)orcid 
Publication Date: 2009
Handle Link: https://hdl.handle.net/1959.11/5229
Abstract: Marbling is a major trait in determining profit in the Korean beef industry. However, the underlying biology of muscles with divergent marbling phenotypes is still poorly understood in cattle. In this study, we attempted to detect differentially expressed genes in M. longissimus dorsi in Hanwoo steers with high and low estimated breeding values for marbling score using an Affymetrix bovine gene expression array. Three data-processing methods (MAS5.0, GCRMA and RMA) were implemented to test for differential expression (DE). Analysis identified 21 transcripts exhibiting significant DE in at least two data-processing methods (P<0.001). Squalene epoxidase and Cytochrome P450 gene, thought to play a role in biotransformation of steroids, were expressed more in highly marbled muscle whereas gene for Arginyl-tRNA synthetase, Ribosomal protein S6 kinase, Thimetoligopeptidase 1, Proteosome activator subunit 4, ATP binding protein and CDC-like kinase gene, which are all involved in protein synthesis and cell division, were down-regulated in highly marbled muscle. These results suggest that down-regulation of genes involved in cell division, growth regulation and protein synthesis may lead to decreased muscle mass and increased adiposity within muscle.
Publication Type: Conference Publication
Conference Name: 18th Conference of the Association for the Advancement of Animal Breeding and Genetics, Barossa Valley, Australia, 27th September - 2nd October, 2009
Source of Publication: Proceedings of the 18th Conference of the Association for the Advancement of Animal Breeding and Genetics: Matching Genetics and Environment - a New Look at an Old Topic, p. 179-182
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Taringa, Australia
ISSN: 1328-3227
Field of Research (FOR): 060405 Gene Expression (incl Microarray and other genome-wide approaches)
070202 Animal Growth and Development
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://www.aaabg.org/proceedings18/files/lee179.pdf
http://trove.nla.gov.au/work/36420775
http://aaabg.org/aaabg18/
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