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Title: Vitamin E Reduces Oxidative Stress Markers and Modulates Wound Repair in Aged Animals
Contributor(s): Khalil, Z (author); Khodr, B (author); Howard, Jonathon (author); Watson, Kenneth (author)
Publication Date: 2003
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Abstract: Previous studies from our laboratory demonstrated an age-related functional decline in wound repair. Emerging evidence from our group and others favours the involvement of oxidative damage in the pathogenesis of age-related deficits. The aim of this study was to investigate the impact of vitamin E therapy on modulating oxidative stress markers and repair of full-thickness wounds in aged animals. Twenty four-month-old Sprague-Dawley rats were treated with vitamin E for short-term (40mg/kg, i.p. every other day for 2 weeks) or long-term (for 12 months in advance, 10g/kg, incorporated in food). The results indicate that both treatments were effective in reducing oxidative damage and in accelerating wound closure in aged rats. However, an initial increase in wound size was observed in both treated groups. This side effect of a single antioxidant therapy could reflect the importance of oxidants in the early stages of the repair process.
Publication Type: Conference Publication
Conference Name: Meeting of the Society for Free Radicals Research, European Section, Ioannina, Greece, 26th June - 29th June, 2003
Source of Publication: Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications - Proceedings of the Meeting of the Society for Free Radicals Research, European Section, p. 133-138
Publisher: Medimond
Place of Publication: Bologna, Italy
Field of Research (FOR): 110399 Clinical Sciences not elsewhere classified
Peer Reviewed: Yes
HERDC Category Description: B1 Chapter in a Scholarly Book
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