Title: | White Matter Lesions are Associated with Specific Depressive Symptom Trajectories among Incident Depression and Dementia Populations: Three-City Dijon MRI Study |
Contributor(s): | Tully, Phillip J (author) ; Debette, Stephanie (author); Mazoyer, Bernard (author); Tzourio, Christophe (author) |
Publication Date: | 2017-12-01 |
Early Online Version: | 2017-06-06 |
DOI: | 10.1016/j.jagp.2017.06.003 |
Handle Link: | https://hdl.handle.net/1959.11/51840 |
Abstract: | | Objective:
Evidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia.
Methods:
In this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age:
72 years; 59.5% women) without depression, dementia, or stroke at baseline were studied. Baseline T2-weighted images were obtained in a 1.5-T scanner to quantify WMHs (log cm3). Clinic visits were performed up to five times in a 10-year period to assess incident neurologic diseases and comorbidities. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale and converted to factor z scores, representing somatic symptoms, depressed affect, low positive affect, and interpersonal problems.
Results:
Periventricular WMH volume was uniquely associated with low positive affect among incident depression cases (β = 0.15; 95% confidence interval [CI]: 0.02-0.29; p = 0.026). Deep WMH volume was uniquely associated with depressed affect among incident dementia cases (β = 0.36; 95% CI: 0.05-0.68; p = 0.025). WMH volume (periventricular, deep, and total) was associated with interpersonal problems among persons who developed dementia with depression.
Conclusion:
The findings highlight that regional WMH volumes and specific depressive symptoms have clinical and prognostic relevance to help differentiate between persons at risk for depression and dementia.
Publication Type: | Journal Article |
Source of Publication: | American Journal of Geriatric Psychiatry, 25(12), p. 1311-1321 |
Publisher: | Elsevier Inc |
Place of Publication: | United States of America |
ISSN: | 1545-7214 1064-7481 |
Fields of Research (FoR) 2020: | 520302 Clinical psychology |
Socio-Economic Objective (SEO) 2020: | 200409 Mental health |
Peer Reviewed: | Yes |
HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
Appears in Collections: | Journal Article School of Psychology
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