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https://hdl.handle.net/1959.11/51828
Title: | Resistance of Haemonchus sp. to monepantel and reduced efficacy of a derquantel / abamectin combination confirmed in sheep in NSW, Australia | Contributor(s): | Sales, Narelle (author); Love, Stephen (author) | Publication Date: | 2016-09-15 | Early Online Version: | 2016-08-23 | DOI: | 10.1016/j.vetpar.2016.08.016 | Handle Link: | https://hdl.handle.net/1959.11/51828 | Abstract: | Early in 2015, sheep in a summer rainfall area of NSW, Australia, displayed signs of haemonchosis despite treatment with monepantel. A faecal egg count reduction test (FECRT) was performed on yearlings with natural field infections using various anthelmintics. Only a four-way combination drench achieved a reduction in faecal egg count (FEC) greater than 95%. The combination contained abamectin, albendazole, levamisole and closantel. Treatments with a derquantel/abamectin combination, monepantel and moxidectin reduced FECs by 93, 31, and 30% respectively. Sheep treated with abamectin displayed an increase in FEC of 22%. Larval differentiation counts conducted 10 days post-treatment showed that 100% of survivors were Haemonchus sp. This result confirms for the firsttime monepantel resistant Haemonchus in sheep in NSW, and is amongst the first of the Australian cases in sheep not associated with goats. A second FECRT was performed using sheep from the moxidectin and abamectin treatment groups in the first FECRT. In this second FECRT, monepantel treatment reduced FECs by 51% and 29% in the sheep previously treated with moxidectin and abamectin respectively. This suggests monepantel, in combination with moxidectin, may give some control against severely abamectin resistant Haemonchus. | Publication Type: | Journal Article | Source of Publication: | Veterinary Parasitology, v.228, p. 193-196 | Publisher: | Elsevier BV | Place of Publication: | Netherlands | ISSN: | 1873-2550 0304-4017 |
Fields of Research (FoR) 2020: | 300302 Animal management | Socio-Economic Objective (SEO) 2020: | 280101 Expanding knowledge in the agricultural, food and veterinary sciences | Peer Reviewed: | Yes | HERDC Category Description: | C5 Other Refereed Contribution to a Scholarly Journal |
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Appears in Collections: | Journal Article |
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