Sawczuk, Thomas; Jones, Ben; Welch, Mitchell; Beggs, Clive; Scantlebury, Sean; Till, Kevin

Author(s)

Sawczuk, Thomas

Jones, Ben

Welch, Mitchell

Beggs, Clive

Scantlebury, Sean

Till, Kevin

Publication Date

2021-04

Abstract

Purpose: To evaluate the relative importance and predictive ability of salivary immunoglobulin A (s-IgA) measures with regards to upper respiratory illness (URI) in youth athletes. Methods: Over a 38-week period, 22 youth athletes (age = 16.8 [0.5] y) provided daily symptoms of URI and 15 fortnightly passive drool saliva samples, from which s-IgA concentration and secretion rate were measured. Kernel-smoothed bootstrapping generated a balanced data set with simulated data points. The random forest algorithm was used to evaluate the relative importance (RI) and predictive ability of s-IgA concentration and secretion rate with regards to URI symptoms present on the day of saliva sampling (URIday), within 2 weeks of sampling (URI2wk), and within 4 weeks of sampling (URI4wk). Results: The percentage deviation from average healthy s-IgA concentration was the most important feature for URIday (median RI 1.74, interquartile range 1.41-2.07). The average healthy s-IgA secretion rate was the most important feature for URI4wk (median RI 0.94, interquartile range 0.79-1.13). No feature was clearly more important than any other when URI symptoms were identified within 2 weeks of sampling. The values for median area under the curve were 0.68, 0.63, and 0.65 for URIday, URI2wk, and URI4wk, respectively. Conclusions: The RI values suggest that the percentage deviation from average healthy s-IgA concentration may be used to evaluate the short-term risk of URI, while the average healthy s-IgA secretion rate may be used to evaluate the long-term risk. However, the results show that neither s-IgA concentration nor secretion rate can be used to accurately predict URI onset within a 4-week window in youth athletes.

Citation

International Journal of Sports Physiology and Performance, 16(4), p. 511-516

ISSN

1555-0273

1555-0265

Pubmed ID

33440340

Link

https://hdl.handle.net/1959.11/51724

Publisher

Human Kinetics, Inc

Title

Prediction of Upper Respiratory Illness Using Salivary Immunoglobulin A in Youth Athletes

Type of document

Journal Article

Entity Type

Publication

Author(s)	Sawczuk, Thomas Jones, Ben Welch, Mitchell Beggs, Clive Scantlebury, Sean Till, Kevin
Publication Date	2021-04
Abstract	<p><b><i>Purpose:</i></b> To evaluate the relative importance and predictive ability of salivary immunoglobulin A (s-IgA) measures with regards to upper respiratory illness (URI) in youth athletes. <b><i>Methods:</i></b> Over a 38-week period, 22 youth athletes (age = 16.8 [0.5] y) provided daily symptoms of URI and 15 fortnightly passive drool saliva samples, from which s-IgA concentration and secretion rate were measured. Kernel-smoothed bootstrapping generated a balanced data set with simulated data points. The random forest algorithm was used to evaluate the relative importance (RI) and predictive ability of s-IgA concentration and secretion rate with regards to URI symptoms present on the day of saliva sampling (URI<sub>day</sub>), within 2 weeks of sampling (URI<sub>2wk</sub>), and within 4 weeks of sampling (URI<sub>4wk</sub>). </b><i>Results:</i></b> The percentage deviation from average healthy s-IgA concentration was the most important feature for URIday (median RI 1.74, interquartile range 1.41-2.07). The average healthy s-IgA secretion rate was the most important feature for URI<sub>4wk</sub> (median RI 0.94, interquartile range 0.79-1.13). No feature was clearly more important than any other when URI symptoms were identified within 2 weeks of sampling. The values for median area under the curve were 0.68, 0.63, and 0.65 for URI<sub>day</sub>, URI<sub>2wk</sub>, and URI<sub>4wk</sub>, respectively. <b><i>Conclusions:</i></b> The RI values suggest that the percentage deviation from average healthy s-IgA concentration may be used to evaluate the short-term risk of URI, while the average healthy s-IgA secretion rate may be used to evaluate the long-term risk. However, the results show that neither s-IgA concentration nor secretion rate can be used to accurately predict URI onset within a 4-week window in youth athletes.</p>
Citation	International Journal of Sports Physiology and Performance, 16(4), p. 511-516
ISSN	1555-0273 1555-0265
Pubmed ID	33440340
Link	https://hdl.handle.net/1959.11/51724
Publisher	Human Kinetics, Inc
Title	Prediction of Upper Respiratory Illness Using Salivary Immunoglobulin A in Youth Athletes
Type of document	Journal Article
Entity Type	Publication

Prediction of Upper Respiratory Illness Using Salivary Immunoglobulin A in Youth Athletes

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