Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/51605
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHebart, M Len
dc.contributor.authorHerd, R Men
dc.contributor.authorOddy, V Hen
dc.contributor.authorGeiser, Fen
dc.contributor.authorPitchford, W Sen
dc.date.accessioned2022-04-14T04:15:54Z-
dc.date.available2022-04-14T04:15:54Z-
dc.date.issued2021-
dc.identifier.citationAnimal Production Science, 61(13), p. 1303-1314en
dc.identifier.issn1836-5787en
dc.identifier.issn1836-0939en
dc.identifier.urihttps://hdl.handle.net/1959.11/51605-
dc.description.abstract<p> <b> <i> Context. </b> </i> Mice bred to be genetically different in feed efficiency were used in this experiment designed to help improve our knowledge of the biological basis of variation in feed efficiency between individual animals. <p> <b> <i> Aims. </b> </i> This experiment used mice to explore the metabolic basis of genetic variation in feed efficiency in the growing animal. </p><p><b><i>Methods.</i></b> Mice bred to differ in residual feed intake (RFI) recorded over a postweaning test were used. After 11 generations of divergent selection, mice in groups were tested for RFI from 6 to 8, 8 to 10, and 10 to 12 weeks of age, and measured for traits describing the ability to digest feed, body composition, protein turnover, basal and resting metabolic rate, and level of activity. </p> <p> <b> <i> Key results. </b> </i> Compared with the low-RFI (high efficiency) line mice, high-RFI mice consumed 28% more feed per day over their RFI-test, were no heavier, were leaner (16% less total fat per unit of bodyweight), did not differ in the fractional synthesis rate of protein in skeletal muscle or in liver, and had similar basal metabolic rates at 33°C. On an energy basis, the selection lines did not differ in energy retained in body tissue gain, which represented only 1.8% of metabolisable energy intake. The remaining 98.2% was lost as heat. Of the processes measured contributing to the higher feed intake by the high-RFI mice, 47% of the extra feed consumed was lost in faeces and urine, activity was 84% higher and accounted for 24%, the cost of protein gain was 6% higher and accounted for 2%, and the energy cost of digesting and absorbing the extra feed consumed and basal heat production could have accounted for 11 and 15% each. </p> <p> <b> <i> Conclusions. </b> </i> Selection for low RFI (high efficiency) in mice was accompanied by an increase in body fat, an improvement in the process of digestion, a lower rate of protein turnover and a much lower level of activity. Selection did not result in major change in basal metabolic rate. </p> <p> <b> <i> Implications. </i> </b> This experiment with mice provided new information on the biological basis of genetic differences in feed efficiency. The experiment investigated the relative importance of major energy-consuming metabolic processes and was able to quantify the responses in protein turnover and level of activity, being responses in energy-consuming processes that have proven difficult to quantitatively demonstrate in large farm animals. </p>en
dc.languageenen
dc.publisherCSIRO Publishingen
dc.relation.ispartofAnimal Production Scienceen
dc.titleSelection for lower residual feed intake in mice is accompanied by increased body fatness and lower activity but not lower metabolic rateen
dc.typeJournal Articleen
dc.identifier.doi10.1071/AN20664en
local.contributor.firstnameM Len
local.contributor.firstnameR Men
local.contributor.firstnameV Hen
local.contributor.firstnameFen
local.contributor.firstnameW Sen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.schoolSchool of Environmental and Rural Scienceen
local.profile.emailrherd3@une.edu.auen
local.profile.emailhoddy2@une.edu.auen
local.profile.emailfgeiser@une.edu.auen
local.output.categoryC1en
local.record.placeauen
local.record.institutionUniversity of New Englanden
local.publisher.placeAustraliaen
local.format.startpage1303en
local.format.endpage1314en
local.identifier.scopusid85105999775en
local.peerreviewedYesen
local.identifier.volume61en
local.identifier.issue13en
local.contributor.lastnameHebarten
local.contributor.lastnameHerden
local.contributor.lastnameOddyen
local.contributor.lastnameGeiseren
local.contributor.lastnamePitchforden
dc.identifier.staffune-id:rherd3en
dc.identifier.staffune-id:hoddy2en
dc.identifier.staffune-id:fgeiseren
local.profile.orcid0000-0003-4689-5519en
local.profile.orcid0000-0003-1783-1049en
local.profile.orcid0000-0001-7621-5049en
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.profile.roleauthoren
local.identifier.unepublicationidune:1959.11/51605en
local.date.onlineversion2021-05-11-
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
dc.identifier.academiclevelAcademicen
local.title.maintitleSelection for lower residual feed intake in mice is accompanied by increased body fatness and lower activity but not lower metabolic rateen
local.relation.fundingsourcenoteNSW Department of Primary Industries, the University of New England and the former Cooperative Research Centre for the Cattle and Beef Industry (Meat Quality)en
local.output.categorydescriptionC1 Refereed Article in a Scholarly Journalen
local.search.authorHebart, M Len
local.search.authorHerd, R Men
local.search.authorOddy, V Hen
local.search.authorGeiser, Fen
local.search.authorPitchford, W Sen
local.uneassociationYesen
local.atsiresearchNoen
local.sensitive.culturalNoen
local.identifier.wosid000648973600001en
local.year.available2021en
local.year.published2021en
local.fileurl.closedpublishedhttps://rune.une.edu.au/web/retrieve/344120ea-7db5-4fab-abd1-a0cf5a04c016en
local.subject.for2020310907 Animal physiological ecologyen
local.subject.for2020310912 Comparative physiologyen
local.subject.seo2020180606 Terrestrial biodiversityen
Appears in Collections:Journal Article
School of Environmental and Rural Science
Files in This Item:
1 files
File SizeFormat 
Show simple item record

SCOPUSTM   
Citations

1
checked on Mar 16, 2024

Page view(s)

858
checked on Mar 8, 2023
Google Media

Google ScholarTM

Check

Altmetric


Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.