Moghaddar, N

Bunter, K L

Swan, A A

Li, L

Gurman, P M

van der Werf, J H J

2021

Paper presented by Nasir Moghaddar

<i>Growth differentiation factor 9</i> (<i>GDF9</i>) is a known autosomal gene which regulates ovulation rate in mammals. In sheep, numerous polymorphisms have been reported in coding regions of <i>GDF9</i> with a significant impact on ovulation rate and hence litter size. To study the effect of <i>GDF9</i> on litter size in Australian sheep breeds, an association analysis was performed between 1,600,633 imputed sequence single nucleotide polymorphisms (SNPs) on OAR5 and litter size phenotypes in 8,850 Merino and 7,613 maternal sheep breed ewes (predominantly Border Leicester, Coopworth, Corriedale and composite maternal lines) respectively. Results showed a significant association between litter size and SNPs in the <i>GDF9</i> region in maternal breeds. After filtering for high linkage disequilibrium, a highly significant SNP (<i>p_value</i> = 9.09E-09) was found in an intron of the <i>GDF9</i> gene at OAR5:41841588, which accounted for a 0.22 increase in litter size and explained 4.75% of the total genetic variance. This SNP and the surrounding SNPs in the region of <i>GDF9</i> were not significantly associated with litter size in Merinos. Information on this SNP genotype could be useful for obtaining a more accurate estimate of genetic merit for reproduction traits in some breeds of sheep.

Proceedings of the Association for the Advancement of Animal Breeding and Genetics, v.24, p. 238-241

1328-3227

https://hdl.handle.net/1959.11/51591

Association for the Advancement of Animal Breeding and Genetics (AAABG)

The effect of GDF9 on litter size in Australian sheep

Conference Publication

Publication