Please use this identifier to cite or link to this item:
Title: The genetic relationship between female reproductive traits and six psychiatric disorders
Contributor(s): Ni, Guiyan  (author); Amare, Azmeraw T (author); Zhou, Xuan (author); Mills, Natalie (author); Gratten, Jacob (author); Lee, Sang Hong  (author)
Publication Date: 2019-08-19
Open Access: Yes
DOI: 10.1038/s41598-019-48403-x
Handle Link:

Female reproductive behaviours have important implications for evolutionary fitness and health of offspring. Here we used the second release of UK Biobank data (N = 220,685) to evaluate the association between five female reproductive traits and polygenic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N = 429,178). We found that the PRS of attention-deficit/hyperactivity disorder (ADHD) were strongly associated with age at first birth (AFB) (genetic correlation of -0.68 ± 0.03), age at first sexual intercourse (AFS) (-0.56 ± 0.03), number of live births (NLB) (0.36 ± 0.04) and age at menopause (-0.27 ± 0.04). There were also robustly significant associations between the PRS of eating disorder (ED) and AFB (0.35 ± 0.06), ED and AFS (0.19 ± 0.06), major depressive disorder (MDD) and AFB (-0.27 ± 0.07), MDD and AFS (-0.27 ± 0.03) and schizophrenia and AFS (-0.10 ± 0.03). These associations were mostly explained by pleiotropic effects and there was little evidence of causal relationships. Our findings can potentially help improve reproductive health in women, hence better child outcomes. Our findings also lend partial support to the evolutionary hypothesis that causal mutations underlying psychiatric disorders have positive effects on reproductive success.

Publication Type: Journal Article
Grant Details: NHMRC/1080157
Source of Publication: Scientific Reports, v.9, p. 1-12
Publisher: Nature Publishing Group
Place of Publication: United Kingdom
ISSN: 2045-2322
Fields of Research (FoR) 2020: 310501 Anthropological genetics
Socio-Economic Objective (SEO) 2020: 280103 Expanding knowledge in the biomedical and clinical sciences
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Environmental and Rural Science

Files in This Item:
2 files
File Description SizeFormat 
openpublished/TheGeneticNi2019JournalArticle.pdfPublished version2.42 MBAdobe PDF
Download Adobe
Show full item record


checked on May 20, 2023

Page view(s)

checked on Mar 9, 2023


checked on Mar 9, 2023
Google Media

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons