Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/5136
Title: | Intron-exon patterns as a potential tool in studying gene evolution | Contributor(s): | Ruvinsky, Anatoly (author) | Publication Date: | 2009 | Handle Link: | https://hdl.handle.net/1959.11/5136 | Abstract: | The majority of introns are ancient elements and their phases and positions in genes were preserved for a long time. A string of intron phases represents a structure which carries essential information about organization and evolution of genes, which is usually ignored. Numerous observed strings have non-random intron phase patterns caused by intragenic repeats. Correlation between the lengths of CDS and the number of introns per human gene is high. Lengths of exons often remain constant in homologous and even paralogous genes belonging to distant species. Alignment of exon-intron strings provides useful visualization and generates new knowledge about evolution of gene families. It unravels intragenic duplications, intron gains and losses as well as extensions and contractions of exons. This additional information seems to be useful for studying gene evolution. | Publication Type: | Journal Article | Source of Publication: | Vestnik VoGIS: Informatsionnyi Vestnik VoGIS [VOGiS Herald: The Herald of Vavilov Society for Geneticists and Breeding Scientists], 13(1), p. 91-95 | Publisher: | Rossiiskaya Akademiya Nauk | Place of Publication: | Russia | ISSN: | 1814-5558 1814-554X |
Fields of Research (FoR) 2008: | 060408 Genomics | Socio-Economic Objective (SEO) 2008: | 970106 Expanding Knowledge in the Biological Sciences | Peer Reviewed: | Yes | HERDC Category Description: | C1 Refereed Article in a Scholarly Journal | Publisher/associated links: | http://www.bionet.nsc.ru/vogis/pict_pdf/2009/Intron-exon%20patterns%20as%20a%20potentional%20tool%20in%20studying%20gene%20evolution.pdf |
---|---|
Appears in Collections: | Journal Article |
Files in This Item:
File | Description | Size | Format |
---|
Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.