Bagheri, Ali; Yeow, Jonathan; Arandiyan, Hamidreza; Xu, Jiangtao; Boyer, Cyrille; Lim, May

Author(s)

Bagheri, Ali

Yeow, Jonathan

Arandiyan, Hamidreza

Xu, Jiangtao

Boyer, Cyrille

Lim, May

Publication Date

2016-06

Abstract

The polymerization of the photocleavable monomer, o-nitrobenzyl methacrylate (NBMA), is investigated using photoinduced electron/energy transfer reversible addition-fragmentation chain transfer polymerization. The polymerizations under visible red (λ max = 635 nm, 0.7 mW cm-2) and yellow (λ max = 560 nm, 9.7 mW cm-2) light are performed and demonstrate rational evidence of a controlled/living radical polymerization process. Well-defined poly(o-nitrobenzyl methacrylate) (PNBMA) homopolymers with good control over the molecular weight and polymer dispersity are successfully synthesized by varying the irradiation time and/or targeted degree of polymerization. Chain extension of a poly(oligo(ethylene glycol) methyl ether methacrylate) macro-chain transfer agent with NBMA is carried out to fabricate photocleavable amphiphilic block copolymers (BCP). Finally, these self-assembled BCP rapidly dissemble under UV light suggesting the photoresponsive character of NBMA is not altered during the polymerization under yellow or red light. Such photoresponsive polymers can be potentially used for the remote-controlled delivery of therapeutic compounds.

Citation

Macromolecular Rapid Communications, 37(11), p. 905-910

ISSN

1521-3927

1022-1336

Pubmed ID

27121222

Link

https://hdl.handle.net/1959.11/51339

Publisher

Wiley-VCH Verlag GmbH & Co KGaA

Title

Polymerization of a Photocleavable Monomer Using Visible Light

Type of document

Journal Article

Entity Type

Publication

Author(s)	Bagheri, Ali Yeow, Jonathan Arandiyan, Hamidreza Xu, Jiangtao Boyer, Cyrille Lim, May
Publication Date	2016-06
Abstract	<p>The polymerization of the photocleavable monomer, o-nitrobenzyl methacrylate (NBMA), is investigated using photoinduced electron/energy transfer reversible addition-fragmentation chain transfer polymerization. The polymerizations under visible red (λ <sub>max</sub> = 635 nm, 0.7 mW cm<sup>-2</sup>) and yellow (λ <sub>max</sub> = 560 nm, 9.7 mW cm<sup>-2</sup>) light are performed and demonstrate rational evidence of a controlled/living radical polymerization process. Well-defined poly(o-nitrobenzyl methacrylate) (PNBMA) homopolymers with good control over the molecular weight and polymer dispersity are successfully synthesized by varying the irradiation time and/or targeted degree of polymerization. Chain extension of a poly(oligo(ethylene glycol) methyl ether methacrylate) macro-chain transfer agent with NBMA is carried out to fabricate photocleavable amphiphilic block copolymers (BCP). Finally, these self-assembled BCP rapidly dissemble under UV light suggesting the photoresponsive character of NBMA is not altered during the polymerization under yellow or red light. Such photoresponsive polymers can be potentially used for the remote-controlled delivery of therapeutic compounds.</p>
Citation	Macromolecular Rapid Communications, 37(11), p. 905-910
ISSN	1521-3927 1022-1336
Pubmed ID	27121222
Link	https://hdl.handle.net/1959.11/51339
Publisher	Wiley-VCH Verlag GmbH & Co KGaA
Title	Polymerization of a Photocleavable Monomer Using Visible Light
Type of document	Journal Article
Entity Type	Publication

Polymerization of a Photocleavable Monomer Using Visible Light

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