Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/46928
Title: Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice
Contributor(s): Sathkumara, Harindra D (author); Hansen, Karyna (author); Miranda-Hernandez, Socorro (author); Govan, Brenda (author); Rush, Catherine M (author); Henning, Lars (author); Ketheesan, Natkunam  (author)orcid ; Kupz, Andreas (author)
Publication Date: 2020-12-16
Open Access: Yes
DOI: 10.1128/AAC.01422-20Open Access Link
Handle Link: https://hdl.handle.net/1959.11/46928
Abstract: Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.
Publication Type: Journal Article
Grant Details: NHMRC/APP1052764
NHMRC/APP1140709
NHMRC/APP1120808
Source of Publication: Antimicrobial Agents and Chemotherapy, 65(1), p. 1-5
Publisher: American Society for Microbiology
Place of Publication: United States of America
ISSN: 1098-6596
0066-4804
Fields of Research (FoR) 2020: 320211 Infectious diseases
320701 Medical bacteriology
Socio-Economic Objective (SEO) 2020: 200104 Prevention of human diseases and conditions
240801 Human biological preventatives
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article
School of Science and Technology

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