Available georeferenced environmental layers are facilitating new insights into global environmental assets and their vulnerability to anthropogenic inputs. Geographically gridded data of agricultural pesticides are crucial to assess human and ecosystem exposure to potential and recognised toxicants. However, pesticides inventories are often sparse over time and by region, mostly report aggregated classes of active ingredients, and are generally fragmented across local or government authorities, thus hampering an integrated global analysis of pesticide risk. Here, we introduce PEST-CHEMGRIDS, a comprehensive database of the 20 most used pesticide active ingredients on 6 dominant crops and 4 aggregated crop classes at 5 arc-min resolution (about 10km at the equator) projected from 2015 to 2025. To estimate the global application rates of specifc active ingredients we use spatial statistical methods to re-analyse the USGS/PNSP and FAOSTAT pesticide databases along with other public inventories including global gridded data of soil physical properties, hydroclimatic variables, agricultural quantities, and socio-economic indices. PEST-CHEMGRIDS can be used in global environmental modelling, assessment of agrichemical contamination, and risk analysis.