Identification of antibacterial constituents from the indigenous Australian medicinal plant 'Eremophila duttonii' F. Muell. ('Myoporaceae')

Title
Identification of antibacterial constituents from the indigenous Australian medicinal plant 'Eremophila duttonii' F. Muell. ('Myoporaceae')
Publication Date
2007
Author(s)
Smith, Joshua Eachan
Tucker, David
Watson, Kenneth
Jones, Graham Lloyd
( author )
OrcID: https://orcid.org/0000-0002-6435-1542
Email: gjones2@une.edu.au
UNE Id une-id:gjones2
Type of document
Journal Article
Language
en
Entity Type
Publication
Publisher
Elsevier Ireland Ltd
Place of publication
Ireland
DOI
10.1016/j.jep.2007.03.031
UNE publication id
une:4368
Abstract
This paper reports on the isolation and identification of antibacterial constituents from the indigenous Australian medicinal plant 'Eremophila duttonii' F. Muell. (Myoporaceae). Preparations derived from this plant are used by indigenous populations in the topical treatment of minor wounds, otitis and ocular complaints, and as a gargle for sore throat. Several authors have reported extracts of this plant to effect rapid bacteriolysis and inhibit growth of a wide range of Gram-positive micro-organisms. In other studies involving screening of native medicinal plants for antibacterial activity, extracts of 'Eremophila duttonii' have been reported to consistently exhibit the highest potency amongst all species included. From a hexane extract, we identified two diterpenes of the serrulatane class, the principal constituents responsible for antibacterial activity and present as major constituents of the resinous leaf cuticle: serrulat-14-en-7,8,20-triol (1) and serrulat-14-en-3,7,8,20-tetraol (2). In addition, a hydroxylated furanosesquiterpene with mild antibacterial activity which appeared to be a novel compound was isolated from the extract and tentatively identified as 4-hydroxy-4-methyl-1-(2,3,4,5-tetrahydro-5-methyl[2,3′-bifuran]-5-yl) pentan-2-one. Minimum inhibitory concentrations for each of the compounds against three Gram-positive bacteria: Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228) and Streptococcus pneumoniae (ARL 10582), were determined using a micro-titre plate broth dilution assay.
Link
Citation
Journal of Ethnopharmacology, 112(2), p. 386-393
ISSN
1872-7573
0378-8741
Start page
386
End page
393

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