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Title: Identification of antibacterial constituents from the indigenous Australian medicinal plant 'Eremophila duttonii' F. Muell. ('Myoporaceae')
Contributor(s): Smith, Joshua Eachan (author); Tucker, David  (author); Watson, Kenneth  (author); Jones, Graham Lloyd  (author)orcid 
Publication Date: 2007
DOI: 10.1016/j.jep.2007.03.031
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Abstract: This paper reports on the isolation and identification of antibacterial constituents from the indigenous Australian medicinal plant 'Eremophila duttonii' F. Muell. (Myoporaceae). Preparations derived from this plant are used by indigenous populations in the topical treatment of minor wounds, otitis and ocular complaints, and as a gargle for sore throat. Several authors have reported extracts of this plant to effect rapid bacteriolysis and inhibit growth of a wide range of Gram-positive micro-organisms. In other studies involving screening of native medicinal plants for antibacterial activity, extracts of 'Eremophila duttonii' have been reported to consistently exhibit the highest potency amongst all species included. From a hexane extract, we identified two diterpenes of the serrulatane class, the principal constituents responsible for antibacterial activity and present as major constituents of the resinous leaf cuticle: serrulat-14-en-7,8,20-triol (1) and serrulat-14-en-3,7,8,20-tetraol (2). In addition, a hydroxylated furanosesquiterpene with mild antibacterial activity which appeared to be a novel compound was isolated from the extract and tentatively identified as 4-hydroxy-4-methyl-1-(2,3,4,5-tetrahydro-5-methyl[2,3′-bifuran]-5-yl) pentan-2-one. Minimum inhibitory concentrations for each of the compounds against three Gram-positive bacteria: Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228) and Streptococcus pneumoniae (ARL 10582), were determined using a micro-titre plate broth dilution assay.
Publication Type: Journal Article
Source of Publication: Journal of Ethnopharmacology, 112(2), p. 386-393
Publisher: Elsevier Ireland Ltd
Place of Publication: Ireland
ISSN: 1872-7573
Fields of Research (FoR) 2008: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio-Economic Objective (SEO) 2008: 920109 Infectious Diseases
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Appears in Collections:Journal Article

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