Please use this identifier to cite or link to this item: https://hdl.handle.net/1959.11/4133
Title: Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs
Contributor(s): Piper, E (author); Chen, Y (author); Zhang, Yuandan  (author); Tier, Bruce  (author); Graser, Hans Ulrich  (author); Luxford, B G (author); Moran, C (author)
Publication Date: 2007
Handle Link: https://hdl.handle.net/1959.11/4133
Abstract: The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).
Publication Type: Conference Publication
Conference Name: Genetic Improvement - Making it Happen, University of New England, Armidale, NSW, Australia, September 23 - September 26 2007
Conference Details: Genetic Improvement - Making it Happen, University of New England, Armidale, NSW, Australia, September 23 - September 26 2007
Source of Publication: Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics, p. 53-56
Publisher: AAABG: Association for the Advancement of Animal Breeding and Genetics
Place of Publication: Armidale, NSW, Australia
ISSN: 1328-3227
Field of Research (FOR): 060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)
Socio-Economic Outcome Codes: 830308 Pigs
Peer Reviewed: Yes
HERDC Category Description: E1 Refereed Scholarly Conference Publication
Other Links: http://www.aaabg.org/livestocklibrary/2007/piper053.pdf
http://trove.nla.gov.au/work/35062558?selectedversion=NBD42373479
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Appears in Collections:Animal Genetics and Breeding Unit (AGBU)
Conference Publication

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