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|Title:||Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs||Contributor(s):||Piper, E (author); Chen, Y (author); Zhang, Yuandan (author); Tier, Bruce (author); Graser, Hans Ulrich (author); Luxford, B G (author); Moran, C (author)||Publication Date:||2007||Handle Link:||https://hdl.handle.net/1959.11/4133||Abstract:||The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).||Publication Type:||Conference Publication||Conference Name:||Genetic Improvement - Making it Happen, University of New England, Armidale, NSW, Australia, September 23 - September 26 2007||Conference Details:||Genetic Improvement - Making it Happen, University of New England, Armidale, NSW, Australia, September 23 - September 26 2007||Source of Publication:||Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics, p. 53-56||Publisher:||AAABG: Association for the Advancement of Animal Breeding and Genetics||Place of Publication:||Armidale, NSW, Australia||ISSN:||1328-3227||Field of Research (FOR):||060412 Quantitative Genetics (incl Disease and Trait Mapping Genetics)||Socio-Economic Outcome Codes:||830308 Pigs||Peer Reviewed:||Yes||HERDC Category Description:||E1 Refereed Scholarly Conference Publication||Other Links:||http://www.aaabg.org/livestocklibrary/2007/piper053.pdf
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|Appears in Collections:||Animal Genetics and Breeding Unit (AGBU)|
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